Evidence map›Paper›PMID 33304838›Full record

ArticleBiotechnology reports (Amsterdam, Netherlands)2020

Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant

Bastian Bartling, Nora C Brüchle, Johanna S Rehfeld, Daniel Boßmann, Timm Fiebig, Christa Litschko, Jörg Fohrer, Rita Gerardy-Schahn, Thomas Scheper, Sascha Beutel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology reports (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bastian BartlingInstitute of Technical Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Nora C BrüchleInstitute of Technical Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Johanna S RehfeldInstitute of Technical Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Daniel BoßmannInstitute of Technical Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Timm FiebigInstitute of Clinical Biochemistry, Hannover Medical School, D-30625 Hannover, Germany.
Christa LitschkoInstitute of Clinical Biochemistry, Hannover Medical School, D-30625 Hannover, Germany.
Jörg FohrerInstitute of Organic Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Rita Gerardy-SchahnInstitute of Clinical Biochemistry, Hannover Medical School, D-30625 Hannover, Germany.
Thomas ScheperInstitute of Technical Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Sascha BeutelInstitute of Technical Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany.
Leibniz University Hannover · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polysialic acid (polySia) are α2,8- and/or α2,9-linked homopolymers with interesting properties for meningococcal vaccine development or the cure of human neurodegenerative disorders. With the goal to avoid large scale production of pathogenic bacteria, we compare in the current study the efficacy of conventional polySia production to recombinant approaches using the engineered laboratory safety strain

Indexed as

Escherichia coliHigh cell densityNMR spectroscopyPolysialic acid

Identifiers

PMID33304838
PMCPMC7711218
OpenAlexW3109551283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.