ArticleJournal of bone oncology2021
Alkaline phosphatase (alp) levels in multiple myeloma and solid cancers with bone lesions: Is there any difference?
Article in Journal of bone oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Prognostic influence of clinicopathological and laboratory factors on colorectal cancer survival in Amhara region oncology centers, retrospective cohort study, Ethiopia, 2024.Discover oncology · 2026Article
- Retrospective cohort study on alkaline phosphatase and ICU mortality rate of multiple myeloma.Scientific reports · 2025Article
- Long-term Evolution of Hypophosphatemia and Osteomalacia in a Patient With Multiple Myeloma.JCEM case reports · 2024Article
- Recurrent central odontogenic fibroma in a patient with nevoid basal cell carcinoma syndrome: case report and in vitro analysis.Oral surgery, oral medicine, oral pathology and oral radiology · 2024Article
- A novel and sensitive ratiometric fluorescent quantum dot-based biosensor for alkaline phosphatase detection in biological samplesRSC advances · 2023Article
- Validation of a Diagnostic Model to Differentiate Multiple Myeloma from Bone Metastasis.Clinical epidemiology · 2023Article
- Microporous structures on mineralized collagen mediate osteogenesis by modulating the osteo-immune response of macrophages.Frontiers in bioengineering and biotechnology · 2022Article
- Modern markers for evaluating bone disease in multiple myeloma (Review).Experimental and therapeutic medicine · 2021Review
- Development of a clinical diagnostic tool to differentiate multiple myeloma from bone metastasis in patients with destructive bone lesions (MM-BM DDx).BMC family practice · 2020Article
- Electrochemical Detection and Capillary Electrophoresis: Comparative Studies for Alkaline Phosphatase (ALP) Release from Living Cells.Biosensors · 2020Article
- Overview of Optical and Electrochemical Alkaline Phosphatase (ALP) Biosensors: Recent Approaches in Cells Culture Techniques.Biosensors · 2019Review
- Educational Case: Paget disease of bone.Academic pathologyArticle
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBone involvement in Multiple Myeloma results from increased osteoclast formation and activity that occurs in proximity to myeloma cells. The role of Alkaline Phosphatse (ALP) in this process and the diagnostic significance of plasma levels in patients with MM are unclear.
aimTo compare plasma ALP levels in patients with MM and solid cancers and metastatic lesions to the bone.
resultsIn this observational retrospective study we enrolled 901 patients were enrolled: 440 patients (49%) with Multiple Myeloma, 461 (51%) with solid cancers. All 901 patients had bone lesions. Among patients with Multiple Myeloma, ALP values were mainly in the range of normality than those observed in patients with solid cancers and bone lesions. This difference is independent of stage, number and type of bone lesions.
conclusionThis study suggests that plasma ALP has a different clinical significance in MM than in other neoplasms and could be used as a discriminating marker in presence of bone lesions. In particular, lower or normal values, should suggest further investigations such as urinary and serum electrophoresis, associated with bone marrow aspirate in case of the presence of a monoclonal component, in order to confirm or exclude a MM diagnosis.
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