ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.
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In one paragraph
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 31 citations in OpenAlex.
- Human iPSC-derived neural progenitor cells rescue motor function and brain pathology in symptomatic Canavan disease mice.Stem cell reports · 2026Article
- A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms.NPJ genomic medicine · 2025Article
- Targeting glioblastoma using oncolytic viruses delivered by human pluripotent stem cell-derived neural progenitor cells.Molecular therapy. Oncology · 2025Article
- Electromagnetic Cellularized Patch with Wirelessly Electrical Stimulation for Promoting Neuronal Differentiation and Spinal Cord Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications.Signal transduction and targeted therapy · 2024Review
- Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies.Cells · 2024Review
- Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease.Cell & bioscience · 2024Review
- Leukodystrophy Imaging: Insights for Diagnostic Dilemmas.Medical sciences (Basel, Switzerland) · 2024Review
- The Role of Induced Pluripotent Stem Cells in the Treatment of Stroke.Current neuropharmacology · 2024Review
- Developing a human iPSC-derived three-dimensional myelin spheroid platform for modeling myelin diseases.iScience · 2023Article
- The Apolipoprotein E neutralizing antibody inhibits SARS-CoV-2 infection by blocking cellular entry of lipoviral particles.MedComm · 2023Article
- Developing Hypoimmunogenic Human iPSC-Derived Oligodendrocyte Progenitor Cells as an Off-The-Shelf Cell Therapy for Myelin Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases.Pharmaceutics · 2023Review
- The Journey of iPSC-derived OPCs in Demyelinating Disorders: FromCurrent neuropharmacology · 2023Article
- Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-typeiScience · 2022Article
- Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection.iScience · 2022Article
- Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases.Molecular neurobiology · 2022Review
- Dual-function AAV gene therapy reverses late-stage Canavan disease pathology in mice.Frontiers in molecular neuroscience · 2022Article
- Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice.Annals of neurology · 2021Article
- Mapping the degradation pathway of a disease-linked aspartoacylase variant.PLoS genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 5 institutions in 2 countries.
Lizhao FengDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Jianfei ChaoDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
E TianDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Li LiDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Peng YeDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Mi ZhangDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Xianwei ChenDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Qi CuiDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Guihua SunDiabetes and Metabolism Research Institute at City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Tao ZhouDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Gerardo FelixDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Yue QinDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Wendong LiDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Edward David MezaDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Jeremy KleinDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Lucy GhodaDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Weidong HuDepartment of Molecular Imaging and Therapy Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Yonglun LuoDepartment of Biomedicine Aarhus University Aarhus 8000 Denmark.
Wei DangCenter for Biomedicine and Genetics Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
David HsuCenter for Biomedicine and Genetics Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Joseph GoldCenter for Biomedicine and Genetics Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.
Steven A GoldmanCenter for Translational Neuromedicine University of Rochester Medical Center Rochester NY 14642 USA.
Reuben MatalonDepartment of Pediatrics the University of Texas Medical Branch at Galveston 301 University Blvd Galveston TX 77555-0359 USA.
Yanhong ShiDivision of Stem Cell Biology Research Department of Developmental and Stem Cell Biology Beckman Research Institute of City of Hope 1500 E. Duarte Rd. Duarte CA 91010 USA.ORCID https://orcid.org/0000-0002-3938-5839
City Of Hope National Medical Center · USAarhus University · DKCity of Hope · USThe University of Texas Medical Branch at Galveston · USUniversity of Copenhagen · DK
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MApoE2 in Alzheimer's disease: the neuroprotective effects and mechanismsRF1AG061794 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2018 to 2018
$3.1MModeling Alzheimer’s disease using directly reprogrammed isogenic neural cellsR01AG056305 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, YADONG, SHI, YANHONG · 2017 to 2021
$2.2MAn iPSC based humanized mouse model of dysmyelination in schizophreniaR01MH104701 · NIMH · UNIVERSITY OF ROCHESTER · PI GOLDMAN, STEVEN ALAN · 2014 to 2018
$2.1MTRANSCRIPTIONAL DETERMINANTS OF THE FATE TRAJECTORIES OF SINGLE HUMAN GLIAL PROGENITOR CELLS IN RESPONSE TO DEMYELINATION IN VIVOR01NS110776 · NINDS · UNIVERSITY OF ROCHESTER · PI GOLDMAN, STEVEN ALAN · 2019 to 2023
$1.8MUncovering the molecular and cellular mechanisms underlying AD using CRISPR/Cas9-edited isogenic neural cellsR56AG061171 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2019 to 2019
$629kNCI NIH HHS P30 CA033572NIA NIH HHS R01 AG056305NIA NIH HHS R56 AG061171NIA NIH HHS RF1 AG061794NIMH NIH HHS R01 MH104701NINDS NIH HHS R01 NS110776
Abstract
Canavan disease (CD) is a fatal leukodystrophy caused by mutation of the aspartoacylase (
Indexed as
Canavan diseaseiPSCsleukodystrophyneural progenitor cells (NPCs)neurological diseasesoligodendrocyte progenitor cells (OPCs)stem cell therapy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.