Evidence map›Paper›PMID 33304757›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Transcranial Ultrasound Innovations Ready for Broad Clinical Application.

Roland Beisteiner, Andres M Lozano

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05006365 (Effects of Transcranial Pulse Stimulation), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05006365 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Transcranial Pulse Stimulation (TPS) on Young Adults with Symptoms of Depression - a Pilot Randomized Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2021 to 2023Enrolled30ConditionsMajor Depressive DisorderArmsTranscranial Pulse Stimulation
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Review
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  15. Ultrasound Neuromodulation as a New Brain Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Roland BeisteinerDepartment of Neurology Medical University of Vienna Vienna 1090 Austria.ORCID https://orcid.org/0000-0002-6410-5990
Andres M LozanoDivision of Neurosurgery Department of Surgery University of Toronto Toronto ON M5T 2S8 Canada.
Medical University of Vienna · ATUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain diseases are one of the most important problems in our rapidly ageing society. Currently, there are not many effective medications and surgical options are limited due to invasiveness and non-invasive brain stimulation techniques cannot be well targeted and cannot access deep brain areas. A novel therapy is transcranial ultrasound which allows a variety of treatments without opening of the skull. Recent technological developments generated three revolutionary options including 1) targeted non-invasive surgery, 2) highly targeted drug, antibody, or gene therapy via local opening of the blood-brain barrier, and 3) highly targeted brain stimulation to improve pathological brain functions. This progress report summarizes the current state of the art for clinical application and the results of recent patient investigations.

Indexed as

brain therapyneuropsychiatric diseaseultrasound

Identifiers

PMID33304757
PMCPMC7709976
OpenAlexW3096550593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.