Evidence map›Paper›PMID 33304747›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics.

Fay Nicolson, Akbar Ali, Moritz F Kircher, Suchetan Pal

Open access · goldAbstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
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  10. Aptamer-Based DNA Allosteric Switch for Regulation of Protein Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Fay NicolsonDepartment of Imaging Dana-Farber Cancer Institute & Harvard Medical School Boston MA 02215 USA.
Akbar AliDepartment of Chemistry Indian Institute of Technology- Bhilai Raipur Chhattisgarh 492015 India.
Moritz F KircherDepartment of Imaging Dana-Farber Cancer Institute & Harvard Medical School Boston MA 02215 USA.ORCID https://orcid.org/0000-0003-1575-1467
Suchetan PalDepartment of Chemistry Indian Institute of Technology- Bhilai Raipur Chhattisgarh 492015 India.
Indian Institute of Technology Bhilai · INBrigham and Women's Hospital · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Ultrabright Theranostic SERRS Nanoparticles for Gastrointestinal EndoscopyR01CA222836 · NCI · STANFORD UNIVERSITY · PI ROGALLA, STEPHAN · 2018 to 2023
$3.4M
MRI-Photoacoustic-Raman Nanostars for Pre- and Intraoperative Multimodal ImagingR01EB017748 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI KIRCHER, MORITZ FLORIAN · 2014 to 2017
$1.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA222836NIBIB NIH HHS R01 EB017748
6 · The paper itself

Abstract

In the last two decades, DNA has attracted significant attention toward the development of materials at the nanoscale for emerging applications due to the unparalleled versatility and programmability of DNA building blocks. DNA-based artificial nanomaterials can be broadly classified into two categories: DNA nanostructures (DNA-NSs) and DNA-functionalized nanoparticles (DNA-NPs). More importantly, their use in nanotheranostics, a field that combines diagnostics with therapy via drug or gene delivery in an all-in-one platform, has been applied extensively in recent years to provide personalized cancer treatments. Conveniently, the ease of attachment of both imaging and therapeutic moieties to DNA-NSs or DNA-NPs enables high biostability, biocompatibility, and drug loading capabilities, and as a consequence, has markedly catalyzed the rapid growth of this field. This review aims to provide an overview of the recent progress of DNA-NSs and DNA-NPs as theranostic agents, the use of DNA-NSs and DNA-NPs as gene and drug delivery platforms, and a perspective on their clinical translation in the realm of oncology.

Indexed as

cancerDNA‐nanostructuresnanoparticlestheranostics

Identifiers

PMID33304747
PMCPMC7709992
OpenAlexW3092995259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.