ArticleBiomedical physics & engineering express2019
Development of a scanner-specific simulation framework for photon-counting computed tomography.
Article in Biomedical physics & engineering express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 35 citations in OpenAlex.
- The Accuracy of Noise Measurements in Patient CT Images.Academic radiology · 2026Article
- Dependence of motion artifacts on the starting angle of projection data collection in a nonhelical volume scan of a 320-row CT.Physical and engineering sciences in medicine · 2026Article
- Proton therapy range uncertainty reduction using vendor-agnostic tissue characterization on a virtual photon-counting CT head scan.Medical physics · 2026Article
- Truth-based physics informed estimation of material composition in spectral CT in terms of density and effective atomic number.Physics in medicine and biology · 2026Article
- An in silico evaluation of signal and separability properties of k-edge materials in spectral CT.Scientific reports · 2026Article
- Airway quantifications of bronchitis patients with photon-counting and energy-integrating computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- Development of a customizable model for spectral photon-counting detector CT.Medical physics · 2025Article
- Sensitivity analysis of key CT simulation parameters and their impact on quality of virtual images.Medical physics · 2025Article
- User evaluation of detector performance in clinical photon-counting and energy-integrating CT scanners using DICOM images.Medical physics · 2025Article
- Development of a deep learning based approach for multi-material decomposition in spectral CT: a proof of principle in silico study.Scientific reports · 2025Article
- In silico modeling of a clinical photon-counting CT system: Verification and validation.Medical physics · 2025Article
- The potential of photon-counting CT for the improved precision of lung nodule radiomics.Physics in medicine and biology · 2025Article
- Photon-Counting CT Effects on Sensitivity for Liver Lesion Detection: A Reader Study Using Virtual Imaging.Radiology · 2025Article
- Impact of image formation factors on material discrimination in spectral CT.Physics in medicine and biology · 2024Article
- Toward widespread use of virtual trials in medical imaging innovation and regulatory science.Medical physics · 2024Review
- A framework to model charge sharing and pulse pileup for virtual imaging trials of photon-counting CT.Physics in medicine and biology · 2024Article
- Photon-counting computed tomography versus energy-integrating computed tomography for detection of small liver lesions: comparison using a virtual framework imaging.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Triple-source saddle-curve cone-beam photon counting CT image reconstruction: A simulation study.Zeitschrift fur medizinische Physik · 2024Article
- Development of a separability index for task specific characterization of spectral computed tomography.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2024Article
- A systematic assessment and optimization of photon-counting CT for lung density quantifications.Medical physics · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to develop and validate a simulation platform that generates photon-counting CT images of voxelized phantoms with detailed modeling of manufacturer-specific components including the geometry and physics of the x-ray source, source filtrations, anti-scatter grids, and photon-counting detectors. The simulator generates projection images accounting for both primary and scattered photons using a computational phantom, scanner configuration, and imaging settings. Beam hardening artifacts are corrected using a spectrum and threshold dependent water correction algorithm. Physical and computational versions of a clinical phantom (ACR) were used for validation purposes. The physical phantom was imaged using a research prototype photon-counting CT (Siemens Healthcare) with standard (macro) mode, at four dose levels and with two energy thresholds. The computational phantom was imaged with the developed simulator with the same parameters and settings used in the actual acquisition. Images from both the real and simulated acquisitions were reconstructed using a reconstruction software (FreeCT). Primary image quality metrics such as noise magnitude, noise ratio, noise correlation coefficients, noise power spectrum, CT number, in-plane modulation transfer function, and slice sensitivity profiles were extracted from both real and simulated data and compared. The simulator was further evaluated for imaging contrast materials (bismuth, iodine, and gadolinium) at three concentration levels and six energy thresholds. Qualitatively, the simulated images showed similar appearance to the real ones. Quantitatively, the average relative error in image quality measurements were all less than 4% across all the measurements. The developed simulator will enable systematic optimization and evaluation of the emerging photon-counting computed tomography technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.