Evidence map›Paper›PMID 33304614›Full record

ArticleBiomedical physics & engineering express2019

Cerenkov light transport in scintillation crystals explained: realistic simulation with GATE.

Emilie Roncali, Sun Il Kwon, Sebastien Jan, Eric Berg, Simon R Cherry

Abstract read
In one paragraph

Article in Biomedical physics & engineering express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  4. Article
  5. Article
  6. Timing Performance with Broadcom Metal Trench Silicon Photomultipliers.IEEE transactions on radiation and plasma medical sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Timing Estimation and Limits in TOF-PET Detectors Producing Prompt Photons.IEEE transactions on radiation and plasma medical sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Study of Čerenkov Light Emission in the Semiconductors TlBr and TlCl for TOF-PET.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  16. Article
  17. Review
  18. TOF-PET Image Reconstruction With Multiple Timing Kernels Applied on Cherenkov Radiation in BGO.IEEE transactions on radiation and plasma medical sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emilie RoncaliDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States of America.ORCID 0000-0002-2439-1064
Sun Il KwonDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States of America.ORCID 0000-0002-1810-2123
Sebastien JanIMIV, CEA, Inserm, CNRS, Univ. Paris-Sud, Université Paris Saclay, CEA-SHFJ, 91 400, Orsay, France.
Eric BergDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States of America.
Simon R CherryDepartment of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States of America.ORCID 0000-0002-0155-5644

Funding

Research at the interface of optical and ionizing radiation for innovative cancer imaging and therapyR35CA197608 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHERRY, SIMON R · 2015 to 2021
$4.9M
New optical Monte Carlo simulation tools for nuclear medicineR01EB027130 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RONCALI, EMILIE · 2019 to 2023
$1.5M
NCI NIH HHS R35 CA197608NIBIB NIH HHS R01 EB027130
6 · The paper itself

Abstract

purposeWe are investigating the use of promptly emitted Cerenkov photons to improve scintillation detector timing resolution for time-of-flight (TOF) positron emission tomography (PET). Bismuth germanate (BGO) scintillator was used in most commercial PET scanners until the emergence of lutetium oxyorthosilicate, which allowed for TOF PET by triggering on the fast and bright scintillation signal. Yet BGO is also a candidate to generate fast timing triggers based on Cerenkov light produced in the first few picoseconds following a gamma interaction. Triggering on the Cerenkov light produces excellent timing resolution in BGO but is complicated by the very low number of photons produced. A better understanding of the transport and collection of Cerenkov photons is needed to optimize their use for effective triggering of the detectors.

methodsWe simultaneously generated and tracked Cerenkov and scintillation photons with a new model of light transport that we have released in GATE V8.0. This crystal reflectance model was used to study photon detection and timing properties, building realistic waveforms as measured with silicon photomultipliers.

resultsWe compared the behavior and effect of detecting Cerenkov and scintillation photons at several levels, including detection time stamps, travel time, and coincidence resolving time in 3 × 3 × 20 mm POTENTIAL APPLICATIONS: To our knowledge, this is the first complete simulation of the generation, transport, and detection of the combination of Cerenkov and scintillation photons for TOF detectors. This simulation framework will allow for quantitative study of the factors influencing timing resolution, including the photodetector characteristics, and ultimately aid the development of BGO and other Cerenkov-based detectors for TOF PET.

Indexed as

CerenkovMonte Carlo simulationpositron emission tomographyradiation detectortiming resolution

Identifiers

PMID33304614
PMCPMC7725232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.