ArticleNeuro-oncology practice2020
Multiparameter quantitative histological MRI values in high-grade gliomas: a potential biomarker of tumor progression.
Article in Neuro-oncology practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Bi-specific T cell-engaging antibody triggers protective immune memory and glioma microenvironment remodeling in immune-competent preclinical models.Journal for immunotherapy of cancer · 2025Article
- Article
- Using quantitative magnetic resonance imaging to track cerebral alterations in multiple sclerosis brain: A longitudinal study.Brain and behavior · 2023Article
- Article
- Detection of early alterations in radiologically normal-appearing brain regions before recurrence of high-grade glioma using multiparameter mapping and diffusion tensor imaging.Neuro-oncology advancesArticle
- A fast protocol for multicenter and multiparametric quantitative MRI studies in brain tumor patients using vendor sequences.Neuro-oncology advancesArticle
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Authors and funding
9 authors.
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Abstract
backgroundConventional MRI poorly distinguishes brain parenchyma microscopically invaded by high-grade gliomas (HGGs) from the normal brain. By contrast, quantitative histological MRI (hMRI) measures brain microstructure in terms of physical MR parameters influenced by histochemical tissue composition. We aimed to determine the relationship between hMRI parameters in the area surrounding the surgical cavity and the presence of HGG recurrence.
methodsPatients were scanned after surgery with an hMRI multiparameter protocol that allowed for estimations of longitudinal relaxation rate (R1) = 1/T1, effective transverse relaxation rate (R2)*=1/T2*, magnetization transfer saturation (MT
resultsThirty-one patients with HGG who underwent gross-total resection were enrolled. MT
conclusionsHGG recurrence was associated with hMRI parameters' variation after initial surgery, weeks to months before overt recurrence.
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