ReviewComputational and structural biotechnology journal2020
Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi.
Review in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Genomic instability and biofilm determinants inJournal of bacteriology · 2026Article
- Arbuscular Mycorrhiza Modulates Iron Distribution and Vacuolar Iron Transporter Expression in Tomato, Whereas Iron Limitation Reduces Mycorrhization.Plant, cell & environment · 2026Article
- Vacuolar iron transporters mediate resistance to triadimefon in plant pathogenic fungi.Nature communications · 2026Article
- Nematode-trapping devices of Arthrobotrys oligospora is an iron storage system mediated by elevated temperatures.FEMS microbiology ecology · 2026Article
- A two-step actin-mediated strategy enables Campylobacter jejuni to promote mitochondrial aggregation and iron homeostasis, for intracellular survival and persistence.Communications biology · 2026Article
- Comparative analyses of the biological characteristics, fluconazole resistance, and heat adaptation mechanisms ofApplied and environmental microbiology · 2025Article
- Identification, characterization, and function analysis of the VIT family in Phaeodactylum tricornutum.Scientific reports · 2025Article
- Article
- Discovery of novel targets for important human and plant fungal pathogens via an automated computational pipeline HitList.PloS one · 2025Article
- Transcriptional dynamics during Rhodococcus erythropolis infection with phage WC1.BMC microbiology · 2024Article
- Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants.Journal of experimental botany · 2023Article
- Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.Biochemical Society transactions · 2023Review
- The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii.Nature communications · 2023Article
- Expression and mutagenesis studies in theFrontiers in plant science · 2023Article
- The Multifaceted Gene 275 Embedded in the PKS-PTS Gene Cluster Was Involved in the Regulation of Arthrobotrisin Biosynthesis, TCA Cycle, and Septa Formation in Nematode-Trapping FungusJournal of fungi (Basel, Switzerland) · 2022Article
- A Large-Scale Multiple Genome Comparison of Acidophilic Archaea (pH ≤ 5.0) Extends Our Understanding of Oxidative Stress Responses in Polyextreme Environments.Antioxidants (Basel, Switzerland) · 2021Article
- Orchestrating a heist: uptake and storage of metals by apicomplexan parasites.Microbiology (Reading, England) · 2021Article
- Regulation of iron homeostasis by peroxide-sensitive CatR, a Fur-family regulator in Streptomyces coelicolor.Journal of microbiology (Seoul, Korea) · 2021Article
- Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron.Genes · 2021Article
- Characterization of the substrate binding site of an iron detoxifying membrane transporter from Plasmodium falciparum.Malaria journal · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an essential micronutrient for most living beings since it participates as a redox active cofactor in many biological processes including cellular respiration, lipid biosynthesis, DNA replication and repair, and ribosome biogenesis and recycling. However, when present in excess, iron can participate in Fenton reactions and generate reactive oxygen species that damage cells at the level of proteins, lipids and nucleic acids. Organisms have developed different molecular strategies to protect themselves against the harmful effects of high concentrations of iron. In the case of fungi and plants, detoxification mainly occurs by importing cytosolic iron into the vacuole through the Ccc1/VIT1 iron transporter. New sequenced genomes and bioinformatic tools are facilitating the functional characterization, evolution and ecological relevance of metabolic pathways and homeostatic networks across the Tree of Life. Sequence analysis shows that Ccc1/VIT1 homologs are widely distributed among organisms with the exception of animals. The recent elucidation of the crystal structure of a Ccc1/VIT1 plant ortholog has enabled the identification of both conserved and species-specific motifs required for its metal transport mechanism. Moreover, recent studies in the yeast
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.