ArticleFrontiers in aging neuroscience2020
Effectiveness of an Innovative Cognitive Treatment and Telerehabilitation on Subjects With Mild Cognitive Impairment: A Multicenter, Randomized, Active-Controlled Study.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Italian Network of Telerehabilitation: Evaluation of Telerehabilitation System in Mild Cognitive Impairment
Home-based Virtual Reality Cognitive Training as an add-on to Telerehabilitation in Alzheimer's Disease: Validation of a Protocol to Slow Down Cognitive Decline and Reduce Caregivers' Burden
Who cites it
42 citing papers in PubMed, 12 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Comparing Digital Cognitive Interventions to Active Controls and Usual Care for Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Digital health interventions for older adults with subjective cognitive decline or mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.BMC geriatrics · 2026Pooled it
- Virtual reality-based cognitive training in mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- Toward better technology for social health in dementia: a review of implementation recommendations and research priorities to equitably meet the demand.Frontiers in public health · 2026Pooled it
- Effects of different interventions based on virtual reality on cognitive and motor function in elderly people with mild cognitive impairment or dementia: a systematic review and network meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Leveraging human-robot interaction and virtual reality for digital biomarkers in diagnostics and rehabilitation: a review from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Pooled it
- Virtual Reality Interventions for Older Adults With Mild Cognitive Impairment: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2025Pooled it
- Cognitive rehabilitation using virtual reality in subjective cognitive decline and mild cognitive impairment: a systematic review.Frontiers in psychology · 2025Pooled it
- Effect of home-based lifestyle interventions on cognition in older adults with mild cognitive impairment: a systematic review.BMC geriatrics · 2024Pooled it
- A systematic review of cognitive telerehabilitation in patients with cognitive dysfunction.Frontiers in neurology · 2024Pooled it
- Remote activities of cognitive stimulation for older adults during the COVID-19 pandemic: a systematic review.Cadernos de saude publica · 2024Pooled it
- Effectiveness of online-based cognitive intervention in community-dwelling older adults with cognitive dysfunction: A systematic review and meta-analysis.International journal of geriatric psychiatry · 2023Pooled it
- Efficacy of non-immersive virtual reality-based telerehabilitation on postural stability in Parkinson's disease: a multicenter randomized controlled trial.European journal of physical and rehabilitation medicine · 2023Trial
- A digital health home intervention for people within the Alzheimer's disease continuum: results from the Ability-TelerehABILITation pilot randomized controlled trial.Annals of medicine · 2023Trial
- Trial
- Article
- Intensive multidisciplinary rehabilitation modulates serumFrontiers in cellular neuroscience · 2026Article
- Digital Health Technologies Applied in Patients With Early Cognitive Change: Scoping Review.Journal of medical Internet research · 2025Article
- Smart Digital Solutions for EARLY Treatment of COGNitive Disability (EARLY-COGN^3): A Study Protocol.Brain sciences · 2025Article
- Multidomain Cognitive Tele-Neurorehabilitation Training in Long-Term Post-Stroke Patients: An RCT Study.Brain sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the potential usefulness of cognitive training procedures in normal aging and mild cognitive impairment (MCI) have received increased attention.
objectiveThe main aim of this study was to evaluate the efficacy of the face-to-face cognitive virtual reality rehabilitation system (VRRS) and to compare it to that of face-to-face cognitive treatment as usual for individuals with MCI. Moreover, we assessed the possibility of prolonging the effects of treatment with a telerehabilitation system.
methodsA total of 49 subjects with MCI were assigned to 1 of 3 study groups in a randomized controlled trial design: (a) those who received face-to-face cognitive VRRS (12 sessions of individualized cognitive rehabilitation over 4 weeks) followed by telerehabilitation (36 sessions of home-based cognitive VRRS training, three sessions for week); (b) those who received face-to-face cognitive VRRS followed by at-home unstructured cognitive stimulation (36 sessions of home-based unstructured cognitive stimulation, three sessions for week); and (c) those who received face-to-face cognitive treatment as usual (12 sessions of face-to-face cognitive treatment as usual).
resultsAn improvement in memory, language and visuo-constructional abilities was observed after the end of face-to-face VRRS treatment compared to face-to-face treatment as usual. The application of home-based cognitive VRRS telerehabilitation seems to induce more maintenance of the obtained gains than home-based unstructured stimulation. DISCUSSION: The present study provides preliminary evidence in support of individualized VRRS treatment and telerehabilitation delivery for cognitive rehabilitation and should pave the way for future studies aiming at identifying optimal cognitive treatment protocols in subjects with MCI. CLINICAL
trial registrationwww.ClinicalTrials.gov, identifier NCT03486704.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.