Evidence map›Paper›PMID 33303923›Full record

ArticleBritish dental journal2020

In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice.

Pouya Hassandarvish, Vunjia Tiong, Nurul Azmawati Mohamed, Harsha Arumugam, Abhishek Ananthanarayanan, Murtaza Qasuri, Yacine Hadjiat, Sazaly Abubakar

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In one paragraph

Article in British dental journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
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  8. Efficacy of Mouthwashes Delivered via Dental Unit Waterlines in Reducing Aerosolized Surrogate SARS-CoV-2.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  9. Article
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  13. Coronavirus outbreaks and infection prevention in dentistry: a narrative review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2022
    Review
  14. Virucidal effect of povidone iodine on COVID-19 in the nasopharynx: an open-label randomized clinical trial.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  15. Virucidal Effect of Povidone Iodine on SARS-CoV-2 in Nasopharynx: An Open-label Randomized Clinical Trial.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Pouya HassandarvishTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Malaysia. pouyahassandarvish@um.edu.my.
Vunjia TiongTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Malaysia.
Nurul Azmawati MohamedBasic Medical Sciences 2 Department, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, 55100 Pandan Indah, Kuala Lumpur, Malaysia.
Harsha Arumugam, Mundipharma Singapore Holding Pte Limited, Singapore.
Abhishek Ananthanarayanan, Mundipharma Singapore Holding Pte Limited, Singapore.
Murtaza Qasuri, Mundipharma Singapore Holding Pte Limited, Singapore.
Yacine Hadjiat, Mundipharma Singapore Holding Pte Limited, Singapore.
Sazaly AbubakarTropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Virus particles in respiratory droplets and aerosols generated during medical/dental procedures are a potential source of SARS-CoV-2 cross infection. In the dental setting, oral decontamination could be an important adjunct to personal protective equipment and is recommended by a number of national COVID-19 guidance documents for dental settings.Aim To assess the in vitrovirucidal activity of an oral povidone iodine (PVP-I) product against SARS-CoV-2.Material and methods BETADINE gargle and mouthwash (1% PVP-I) was tested against SARS-CoV-2 virus under both clean and dirty conditions using a suspension assay based on EN14476 methodology. Virucidal activity of the product, undiluted and at 1:2 dilution, was tested at contact times of 15, 30 and 60 seconds. Viral titres were calculated using the Spearman-Kärber method and reported as median tissue culture infectious dose (TCID

Identifiers

PMID33303923
PMCPMC7726738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.