ArticleScientific reports2020
Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
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- A targeted genetic screen identifies Caenorhabditis elegans genes involved in RNAi-independent antiviral defense.Virology · 2025Article
- Rapid Discovery of Potent Neutralizing Antibodies against SARS-CoV-2 through Directed Evolution of SARS-CoV-1 Antibodies.Molecular pharmaceutics · 2025Article
- Structural and Phylogenetic Analysis on the Proofreading Activity of SARS-CoV-2.Current microbiology · 2025Article
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- Beyond COVID-19: the promise of next-generation coronavirus vaccines.Npj viruses · 2024Review
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- Genomic Diversity and Recombination Analysis of the Spike Protein Gene from Selected Human Coronaviruses.Biology · 2024Article
- Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies.Viruses · 2023Article
- Viral Replicon Systems and Their Biosafety Aspects.Applied biosafety : journal of the American Biological Safety Association · 2023Review
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- Review
- Consequences of Genetic Recombination on Protein Folding Stability.Journal of molecular evolution · 2023Article
- COVID-19 Vaccines: Computational tools and Development.Informatics in medicine unlocked · 2023Review
- Investigating Infectious Organisms of Public Health Concern Associated with Wild Meat.Transboundary and emerging diseases · 2023Review
- Applying the digital data and the bioinformatics tools in SARS-CoV-2 research.Computational and structural biotechnology journal · 2023Review
- Neurological manifestation in COVID-19 disease with neuroimaging studies.American journal of neurodegenerative disease · 2023Review
- Review
- Possible recombination between two variants of concern in a COVID-19 patient.Emerging microbes & infections · 2022Article
- The origins of COVID-19 pandemic: A brief overview.Transboundary and emerging diseases · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
To trace the evolution of coronaviruses and reveal the possible origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), we collected and thoroughly analyzed 29,452 publicly available coronavirus genomes, including 26,312 genomes of SARS-CoV-2 strains. We observed coronavirus recombination events among different hosts including 3 independent recombination events with statistical significance between some isolates from humans, bats and pangolins. Consistent with previous records, we also detected putative recombination between strains similar or related to Bat-CoV-RaTG13 and Pangolin-CoV-2019. The putative recombination region is located inside the receptor-binding domain (RBD) of the spike glycoprotein (S protein), which may represent the origin of SARS-CoV-2. Population genetic analyses provide estimates suggesting that the putative introduced DNA within the RBD is undergoing directional evolution. This may result in the adaptation of the virus to hosts. Unsurprisingly, we found that the putative recombination region in S protein was highly diverse among strains from bats. Bats harbor numerous coronavirus subclades that frequently participate in recombination events with human coronavirus. Therefore, bats may provide a pool of genetic diversity for the origin of SARS-CoV-2.
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