Evidence map›Paper›PMID 33303827›Full record

ArticleScientific reports2020

Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice.

Karen Levy, Suchitra Natarajan, Jinghui Wang, Stephanie Chow, Joshua T Eggold, Phoebe E Loo, Rakesh Manjappa, Stavros Melemenidis, Frederick M Lartey, Emil Schüler and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 6 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 6 syntheses or guidelines pooled it, 269 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. The current status of FLASH particle therapy: a systematic review.Physical and engineering sciences in medicine · 2023
    Pooled it
  7. Review
  8. Article
  9. Volumetric FLASH dosimetryPhysics in medicine and biology · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Use of apertures in single-energy pristine Bragg peak FLASH radiotherapy.Journal of applied clinical medical physics · 2026
    Article
  19. Article
  20. Review

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 1 country.

Karen LevyDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Suchitra NatarajanDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Jinghui WangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Stephanie ChowDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Joshua T EggoldDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Phoebe E LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Rakesh ManjappaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Frederick M LarteyDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Emil SchülerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Lawrie SkinnerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Marjan RafatDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Ryan KoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Anna KimDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Duaa H Al-RawiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Rie von EybenDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Oliver DorigoDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kerriann M CaseyDepartment of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Edward E GravesDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Karl BushDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Amy S YuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Albert C KoongDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Peter G MaximDepartment of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Billy W LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA. bwloo@stanford.edu.
Erinn B RankinDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA. erankin@stanford.edu.
Stanford University · USIndiana University – Purdue University Indianapolis · USThe University of Texas MD Anderson Cancer Center · US

Funding

Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
NCI NIH HHS T32 CA009302
6 · The paper itself

Abstract

Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes. In particular, the highly radiosensitive intestine limits the use of radiation for patients with intra-abdominal tumors. In metastatic ovarian cancer, total abdominal irradiation (TAI) was used as an effective postsurgical adjuvant therapy in the management of abdominal metastases. However, TAI fell out of favor due to high toxicity of the intestine. Here we utilized an innovative preclinical irradiation platform to compare the safety and efficacy of TAI ultra-high dose rate FLASH irradiation to conventional dose rate (CONV) irradiation in mice. We demonstrate that single high dose TAI-FLASH produced less mortality from gastrointestinal syndrome, spared gut function and epithelial integrity, and spared cell death in crypt base columnar cells compared to TAI-CONV irradiation. Importantly, TAI-FLASH and TAI-CONV irradiation had similar efficacy in reducing tumor burden while improving intestinal function in a preclinical model of ovarian cancer metastasis. These findings suggest that FLASH irradiation may be an effective strategy to enhance the therapeutic index of abdominal radiotherapy, with potential application to metastatic ovarian cancer.

Indexed as

AnimalsFemaleGastrointestinal TractMiceMice, Inbred C57BLOvarian NeoplasmsRadiation Injuries, ExperimentalRadiotherapy

Identifiers

PMID33303827
PMCPMC7728763
OpenAlexW3112195456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.