ArticleScientific reports2020
Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016-2017).
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Gender differences in the predictive value of serum uric acid for major adverse cardiovascular events in patients with acute coronary syndromes: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- Uncovering Nonlinear Predictors of Serum Biomarker Uric Acid Using Interpretable Machine Learning in Healthy Men.Biomedicines · 2025Article
- Correlation between obesity-related indices and hyperuricemia among the elderly population in China: A cross-sectional study.Medicine · 2025Article
- Associations between lifestyle factors, physiological conditions, and epigenetic age acceleration in an Asian population.Biogerontology · 2025Article
- Continued elevation of creatinine and uric acid in a male athlete: A case report.SAGE open medical case reports · 2024Article
- Kidney damage predictors in children with metabolically healthy and metabolically unhealthy obesity phenotype.International journal of obesity (2005) · 2023Article
- Serum uric acid to creatinine ratio is a useful predictor of all-cause mortality among hypertensive patients.Clinical hypertension · 2023Article
- Vegan Diet Is Associated with a Lower Risk of Chronic Kidney Disease in Patients with Hyperuricemia.Nutrients · 2023Article
- Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013-2020.BMC women's health · 2023Article
- Age at onset of alcohol consumption and its association with alcohol misuse in adulthood.Neuropsychopharmacology reports · 2023Article
- Association between smoking behavior and serum uric acid among the adults: Findings from a national cross-sectional study.PloS one · 2023Article
- Recent advances in nephropathy biomarker detections using paper-based analytical devices.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Review
- Medical Students' Perspective and Knowledge of Asymptomatic Hyperuricemia and Gout Management: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Kidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,042 participants of the 2016-2017 Korea National Health and Nutrition Examination Survey were analysed. The estimated glomerular filtration rate was calculated using the modification of diet in renal disease formula for Koreans. For each sex, uric acid levels were divided into five subsequent categories of increasing levels (Q1, Q2, Q3, Q4, and hyperuricemia). The association between uric acid level and kidney function was investigated using multiple logistic regression. The results showed that the higher the uric acid levels, the greater the odds of reduced kidney function in both sexes. In men, the adjusted odds ratios (95% confidence intervals) for reduced eGFR comparing the hyperuricemia group to the lowest serum uric acid quartile was 5.55 (3.27-9.44), and in women, the odds ratios (95% confidence intervals) was 7.52 (4.39-12.87). Normal weight or underweight in men and overweight in women, as well as diabetes mellitus, hypertension, and physical inactivity were highly associated with reduced kidney function. Our study revealed a dose-response relationship between uric acid levels and kidney function. Therefore, high uric acid level should be considered as a factor that is potentially related to kidney dysfunction in the Korean population.
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