ArticleNature communications2020
An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 96 citations in OpenAlex.
- A neural circuit of food sight-promoted feeding and contextual memory in mice.Nature communications · 2026Article
- The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules.Nature communications · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- CRFR2 in paraventricular thalamus (PVT) mediates heat-induced anxiety in male mice.Cell & bioscience · 2026Article
- Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.Cell stem cell · 2026Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- Projection-defined hypothalamic outputs differentially regulate thermogenesis and lipolysis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bed Nucleus of Stria Terminalis Enkephalin Neurons Contribute to Depletion-Induced Salt Appetite.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Thyrotropin-releasing hormone neurons of different hypothalamic nuclei increase energy expenditure.Nature communications · 2026Article
- GPR75 in glutamatergic neurons regulates body weight.Cell reports · 2026Article
- Glutamatergic dysfunction of astrocytes in paraventricular nucleus of thalamus contributes to adult anxiety susceptibility in adolescent ethanol exposed mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2R+ neurons.iScience · 2026Article
- A consensus guide to preclinical indirect calorimetry experiments.Nature metabolism · 2025Review
- Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.Nature communications · 2025Article
- Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats.American journal of physiology. Endocrinology and metabolism · 2025Article
- CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity.Molecular metabolism · 2025Article
- Gut microbiota regulate insomnia-like behaviors via gut-brain metabolic axis.Molecular psychiatry · 2025Article
- Development and characterization of an Sf-1-Flp mouse model.JCI insight · 2025Article
- Development and Characterization of abioRxiv : the preprint server for biology · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
It is well recognized that ventromedial hypothalamus (VMH) serves as a satiety center in the brain. However, the feeding circuit for the VMH regulation of food intake remains to be defined. Here, we combine fiber photometry, chemo/optogenetics, virus-assisted retrograde tracing, ChR2-assisted circuit mapping and behavioral assays to show that selective activation of VMH neurons expressing steroidogenic factor 1 (SF1) rapidly inhibits food intake, VMH SF1 neurons project dense fibers to the paraventricular thalamus (PVT), selective chemo/optogenetic stimulation of the PVT-projecting SF1 neurons or their projections to the PVT inhibits food intake, and chemical genetic inactivation of PVT neurons diminishes SF1 neural inhibition of feeding. We also find that activation of SF1 neurons or their projections to the PVT elicits a flavor aversive effect, and selective optogenetic stimulation of ChR2-expressing SF1 projections to the PVT elicits direct excitatory postsynaptic currents. Together, our data reveal a neural circuit from VMH to PVT that inhibits food intake.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.