Evidence map›Paper›PMID 33303691›Full record

ArticleMolecular cancer research : MCR2021

N-Acetyl-L-cysteine Promotes

Teng Teng, Mohamed Kamal, Oihana Iriondo, Yonatan Amzaleg, Chunqiao Luo, Amal Thomas, Grace Lee, Ching-Ju Hsu, John D Nguyen, Irene Kang and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. The Pro-Metastatic Roles of ROS.Antioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 3 countries.

Teng Teng *Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Mohamed Kamal *Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0001-8663-8846
Oihana IriondoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0002-7464-5026
Yonatan AmzalegDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Chunqiao LuoBiostatistics Core, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Amal ThomasDepartment of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0003-4494-4487
Grace LeeDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Ching-Ju HsuBridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
John D NguyenDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Irene KangUSC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
James HicksBridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0001-5353-4338
Andrew SmithDepartment of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0001-5353-4338
Richard SpostoBiostatistics Core, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Min YuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California. minyu@med.usc.edu.
University of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
DOCTORAL AND POST-DOCTORAL TRAINING IN CRANIOFACIAL BIOLOGYT90DE021982 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAINE, MICHAEL LANSDELL · 2011 to 2025
$6.2M
Developing Individualized Medicine Targeting Metastatic Breast Cancer Stem CellsDP2CA206653 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIN · 2015 to 2019
$2.6M
NCI NIH HHS DP2 CA206653NCI NIH HHS P30 CA014089NIDCR NIH HHS T90 DE021982
6 · The paper itself

Abstract

Circulating tumor cells (CTC) can be isolated via a minimally invasive blood draw and are considered a "liquid biopsy" of their originating solid tumors. CTCs contain a small subset of metastatic precursors that can form metastases in secondary organs and provide a resource to identify mechanisms underlying metastasis-initiating properties. Despite technological advancements that allow for highly sensitive approaches of detection and isolation, CTCs are very rare and often present as single cells, posing an extreme challenge for

Indexed as

AcetylcysteineAnimalsAntioxidantsBreast NeoplasmsCell Growth ProcessesDNA Copy Number VariationsFemaleHeat-Shock ProteinsHeterograftsHumansMiceNeoplastic Cells, CirculatingOxidative StressScavenger Receptors, Class AAcetylcysteineAntioxidantsHeat-Shock ProteinsSCARA3 protein, humanScavenger Receptors, Class A

Identifiers

PMID33303691
PMCPMC7925378
OpenAlexW3112594147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.