Evidence map›Paper›PMID 33303642›Full record

ArticleGenes & development2021

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.

Jan Padeken, Stephen Methot, Peter Zeller, Colin E Delaney, Veronique Kalck, Susan M Gasser

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Crucial Role of Epigenetic Modifications in Wharton's Jelly Stem Cells.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jan PadekenFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Stephen MethotFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Peter ZellerFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Colin E DelaneyFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Veronique KalckFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Susan M GasserFriedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.ORCID 0000-0003-3610-9123
Friedrich Miescher Institute · CHUniversity of Basel · CH

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
European Research Council 743312NIH HHS P40 OD010440
6 · The paper itself

Abstract

The establishment and maintenance of chromatin domains shape the epigenetic memory of a cell, with the methylation of histone H3 lysine 9 (H3K9me) defining transcriptionally silent heterochromatin. We show here that the

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromosomal Proteins, Non-HistoneDNA Transposable ElementsEmbryo, NonmammalianGene Expression RegulationGene SilencingHeterochromatinHistone-Lysine N-MethyltransferaseHistonesMethylationMutationRNA-Binding ProteinsCaenorhabditis elegans ProteinsChromosomal Proteins, Non-HistoneDNA Transposable ElementsHeterochromatinHistone-Lysine N-MethyltransferaseHistonesLIN-61 protein, C elegansMet-2 protein, C elegansNRDE-3 protein, C elegansRNA-Binding ProteinsSET-25 protein, C elegansArgonauteheterochromatinhistone methyltransferases (HMTs)HMTLIN-61MBT domain proteinsMET-2NRDE-3SET-25transposon silencing

Identifiers

PMID33303642
PMCPMC7778263
OpenAlexW3113075802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.