ArticleThe European respiratory journal2021
Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.
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Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Plasma protein signatures of adult asthma.Allergy · 2024Pooled it
- Multi-ancestry genome-wide association study of asthma exacerbations.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Multi-Ancestry Epigenome-Wide Meta-Analysis Identifies Novel Bulk and Cell-Type-Specific Epigenetic Markers of Asthma with Severe Exacerbations.medRxiv : the preprint server for health sciences · 2026Article
- GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.Allergy · 2025Article
- Precision medicine for asthma treatment: Unlocking the potential of the epigenome and microbiome.The Journal of allergy and clinical immunology · 2025Review
- Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025Review
- Peripheral blood miRNAs are associated with airflow below threshold in children with asthma.Respiratory research · 2025Article
- Are single-nucleotide polymorphisms previously linked to inhaled corticosteroid response associated with obese-asthma in children?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies.The European respiratory journal · 2024Review
- Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.Clinical epigenetics · 2023Article
- Severe Asthma and Biological Therapies: Now and the Future.Journal of clinical medicine · 2023Review
- Human genetics influences microbiome composition involved in asthma exacerbations despite inhaled corticosteroid treatment.The Journal of allergy and clinical immunology · 2023Article
- Current and future developments in the pharmacology of asthma and COPD: ERS seminar, Naples 2022.Breathe (Sheffield, England) · 2023Review
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.The Journal of allergy and clinical immunology · 2022Article
- Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- Review
- Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.The Lancet. Child & adolescent health · 2021Article
- Identification ofJournal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
38 authors at 15 institutions in 8 countries.
Natalia Hernandez-PachecoResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.ORCID https://orcid.org/0000-0002-6313-1847
Susanne J VijverbergDept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Esther Herrera-LuisGenomics and Health Group, Dept of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.ORCID https://orcid.org/0000-0003-4150-5454
Jiang LiThe Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Yang Yie SioDept of Biological Sciences, National University of Singapore, Singapore, Singapore.
Raquel GranellMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Almudena CorralesResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Cyrielle MaroteauDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Ryan LethemMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Javier Perez-GarciaGenomics and Health Group, Dept of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.ORCID https://orcid.org/0000-0001-7813-4381
Niloufar FarzanDept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Katja RepnikCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Mario GorenjakCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.ORCID https://orcid.org/0000-0003-4208-9683
Patricia SoaresAcademic Dept of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.ORCID https://orcid.org/0000-0001-5033-9115
Leila KarimiDept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-1746-3314
Maximilian SchieckDept of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Lina Pérez-MéndezResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.ORCID https://orcid.org/0000-0001-8246-333X
Vojko BerceCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Roger TavendalePopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Celeste EngDept of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Olaia SardonDivision of Paediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.ORCID https://orcid.org/0000-0002-1567-9824
Inger KullDept of Clinical Sciences and Education Södersjukhuset, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.
Somnath MukhopadhyayAcademic Dept of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
Munir PirmohamedDept of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Katia M C VerhammeDept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-8162-4904
Esteban G BurchardDept of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Michael KabeschDept of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Daniel B HawcuttDept of Women's and Children's Health, University of Liverpool, Liverpool, UK.
Erik MelénDept of Clinical Sciences and Education Södersjukhuset, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8248-0663
Uroš PotočnikCenter for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Fook Tim ChewDept of Biological Sciences, National University of Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0003-1337-5146
Kelan G TantisiraThe Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Steve TurnerChild Health, University of Aberdeen, Aberdeen, UK.ORCID https://orcid.org/0000-0001-8393-5060
Colin N PalmerPopulation Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Carlos FloresResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Maria Pino-YanesResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain mdelpino@ull.edu.es.ORCID https://orcid.org/0000-0003-0332-437X
Anke H Maitland-van der ZeeDept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
PiCA and SysPharmPedia consortia
Universidad de La Laguna · ESUniversity of Maribor · SIUniversity of Dundee · GBUtrecht University · NLBrigham and Women's Hospital · USBrighton and Sussex Medical School · GBErasmus MC · NLKarolinska Institutet · SENational University of Singapore · SGUniversity Hospital Regensburg · DEUniversity of Bristol · GBUniversity of California, San Francisco · USUniversity of Liverpool · GBUniversity of Aberdeen · GBUniversity of the Basque Country · ES
Funding
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MSF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2MMICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4MGENOMICS AND PHARMACOGENOMICS OF SYMPTOMS IN ASTHMAR01NR013391 · NINR · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2011 to 2013
$1.3MDepartment of HealthMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MR/L006758/1NCATS NIH HHS UL1 TR001872NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL127332NIEHS NIH HHS R01 ES015794NIGMS NIH HHS RL5 GM118984NINR NIH HHS R01 NR013391Wellcome TrustWellcome Trust 099177/Z/12/ZWellcome Trust 102215/2/13/2
Abstract
rationaleSubstantial variability in response to asthma treatment with inhaled corticosteroids (ICS) has been described among individuals and populations, suggesting the contribution of genetic factors. Nonetheless, only a few genes have been identified to date. We aimed to identify genetic variants associated with asthma exacerbations despite ICS use in European children and young adults and to validate the findings in non-Europeans. Moreover, we explored whether a gene-set enrichment analysis could suggest potential novel asthma therapies.
methodsA genome-wide association study (GWAS) of asthma exacerbations was tested in 2681 children of European descent treated with ICS from eight studies. Suggestive association signals were followed up for replication in 538 European asthma patients. Further evaluation was performed in 1773 non-Europeans. Variants revealed by published GWAS were assessed for replication. Additionally, gene-set enrichment analysis focused on drugs was performed.
results10 independent variants were associated with asthma exacerbations despite ICS treatment in the discovery phase (p≤5×10
conclusionsThe intergenic region of
Indexed as
Anti-Asthmatic AgentsAsthmaAdministration, InhalationAdrenal Cortex HormonesChildGenome-Wide Association StudyHumansYoung AdultAdrenal Cortex HormonesAnti-Asthmatic Agents
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