Evidence map›Paper›PMID 33303525›Full record

ArticleAJNR. American journal of neuroradiology2021

WEB Device Shape Changes in Elastase-Induced Aneurysms in Rabbits.

Y Ding, D Dai, A Rouchaud, K Janot, S Asnafi, D F Kallmes, R Kadirvel

Open access · bronzeAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Persistent flow inside the Woven EndoBridge at angiographic follow-up: A multicenter study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  4. Article
  5. Article
  6. The impact of pre-treatment aneurysm angulation. What happens with WEB devices at follow-up?Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  7. Article
  8. Long-term efficacy and safety of WovenEndoBridge (WEB)-assisted cerebral aneurysm embolization.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Y DingFrom the Department of Radiology (Y.D., D.D., S.A., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4329-3192
D DaiFrom the Department of Radiology (Y.D., D.D., S.A., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4051-6450
A RouchaudDepartment of Interventional Neuroradiology (A.R.), University Hospital, Limoges, France.ORCID 0000-0003-0902-3375
K JanotNeuroradiology Department (K.J.), University Hospital of Tours, Tours, France.ORCID 0000-0002-7305-3125
S AsnafiFrom the Department of Radiology (Y.D., D.D., S.A., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4059-167X
D F KallmesFrom the Department of Radiology (Y.D., D.D., S.A., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-8495-0040
R KadirvelFrom the Department of Radiology (Y.D., D.D., S.A., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota kadir@mayo.edu.ORCID 0000-0002-6786-9953
Mayo Clinic · USUniversité de Limoges · FRUniversité de Tours · FR

Funding

Computational and Biological Approach to Flow DiversionR01NS076491 · NINDS · MAYO CLINIC ROCHESTER · PI Juan R Cebral, DAVID F KALLMES · 2011 to 2026
$7.4M
Development of Intrasaccular Flow Disrupters for Small and Ruptured AneurysmsR44NS097038 · NINDS · SEQUENT MEDICAL, INC. · PI KALLMES, DAVID F, PATTERSON, WILLIAM ROBERT · 2016 to 2016
$1.1M
Development of a second generation intra-sacular cerebral aneurysm flow diverterR43NS071766 · NINDS · SEQUENT MEDICAL, INC. · PI KALLMES, DAVID F, PATTERSON, WILLIAM ROBERT · 2011 to 2011
$261k
NINDS NIH HHS R01 NS076491NINDS NIH HHS R43 NS071766NINDS NIH HHS R44 NS097038
6 · The paper itself

Abstract

background and purposeWhile WEB devices have been shown to be safe and effective for aneurysm treatment, WEB-shape modification compression has been associated with incomplete aneurysm occlusion. We explored the relationship between occlusion rates and WEB-shape modification in different WEB device types in an experimental aneurysm model. MATERIALS AND

methodsElastase-induced aneurysms were created in rabbits and treated with dual-layer (

resultsGrade I or II occlusion was seen in 16 (44%) aneurysms, and grade I, II, or III ("adequate") occlusion was observed in 22 (61.1%) aneurysms at follow-up. WEB-shape modification was observed in 22 (61.1%) aneurysms. WEB-shape modification was higher in single-layer (9/12) and dual-layer (10/12) devices compared with single-layer sphere devices (3/12). Aneurysms with WEB-shape modification had a higher level of thrombus organization in the dome compared with those without WEB-shape modification (68% [15/22] versus 50% [7/14]). WEB-shape modification was not correlated with angiographic or histologic outcomes but was significantly correlated with levels of fibrosis and smooth muscle cells in the aneurysm.

conclusionsWEB-shape modification is not associated with incomplete aneurysm occlusion of WEB devices in the rabbit model but may be related to connective tissue formation and the healing response to WEB device implantation.

Indexed as

Blood Vessel ProsthesisIntracranial AneurysmAnimalsEmbolization, TherapeuticEndovascular ProceduresPancreatic ElastaseRabbitsTreatment OutcomePancreatic Elastase

Identifiers

PMID33303525
PMCPMC7872195
OpenAlexW3112211519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.