ArticleStem cell research & therapy2020
A smart scaffold composed of three-dimensional printing and electrospinning techniques and its application in rat abdominal wall defects.
Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- To infinity and beyond: the promise of data-driven 3D printing of hernia mesh - a primer for surgeons.Hernia : the journal of hernias and abdominal wall surgery · 2025Review
- Innovative Strategies in Hernia Mesh Design: Materials, Mechanics, and Modeling.Materials (Basel, Switzerland) · 2025Review
- Article
- A bionic 3D-printed hydrogel microneedle of composite mesh for abdominal wall defect repair.RSC advances · 2025Article
- Bone Tissue Engineering Scaffolds: Materials and Methods.3D printing and additive manufacturing · 2024Review
- Abdominal wall hernia repair: from prosthetic meshes to smart materials.Materials today. Bio · 2023Review
- Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications.Polymers · 2022Review
- New Insights into the Application of 3D-Printing Technology in Hernia Repair.Materials (Basel, Switzerland) · 2021Review
- Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabricated by combining 3D printing (3DP) and electrospinning (ESP).
methodsBiological composite scaffolds are composed of integrated 3DP interconnected macrofiber and random ESP microfiber networks. The 3DP scaffold retains intact 3D architecture and mechanical properties, while the ESP network serves as a cell entrapment system at the extracellular matrix (ECM) scale. Biological composite scaffolds are implanted in a defective rat abdominal wall to detect if it could induce early vascularization and reconstruction of the tissue defect.
resultsSEM analysis reveals a pore diameter of 424.47 ± 58.49 μm and a porosity of 70.46 ± 2.48% for biological composite scaffolds. In the in vitro test of cell proliferation, biological composite scaffolds do not affect rat dermal fibroblast proliferation in a time- and dose-dependent manner. The animal experiments show tissue remodeling and early angiogenesis as compared to 3DP scaffolds.
conclusionsOur experiment prepares a biological scaffold with both a macro- and microscale structure by ESP and 3DP technology. Thus, the integration of 3DP and ESP techniques provides a new set of smart scaffolds for abdominal wall defect and hernia repair.
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