ArticleBMC psychiatry2020
Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Beyond the label "major depressive disorder"-detailed characterization of study population matters for EEG-biomarker research.Frontiers in neuroscience · 2025Pooled it
- Alteration of Resting Electroencephalography by Acute Caffeine Consumption in Early Phase Psychosis.Clinical EEG and neuroscience · 2022Trial
- Frontal and Parietal Alpha Asymmetry as Biomarkers for Negative Symptoms in Schizophrenia.Psychiatry investigation · 2025Article
- Social functioning and frontal alpha asymmetry in schizophrenia.Journal of psychiatric research · 2025Article
- Meta analysis of resting frontal alpha asymmetry as a biomarker of depression.Npj mental health research · 2025Article
- Abnormal trial-to-trial variability in P300 time-varying directed eeg network of schizophrenia.Medical & biological engineering & computing · 2024Article
- Frontal Alpha Asymmetry and Its Modulation by Monoaminergic Neurotransmitters in Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Review
- Resting-state EEG dynamic functional connectivity distinguishes non-psychotic major depression, psychotic major depression and schizophrenia.Molecular psychiatry · 2024Article
- Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis.BJPsych open · 2024Article
- Clinical Implication of Maumgyeol Basic Service-the 2 Channel Electroencephalography and a Photoplethysmogram-based Mental Health Evaluation Software.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Functional role of frontal electroencephalogram alpha asymmetry in the resting state in patients with depression: A review.World journal of clinical cases · 2023Review
- Resting-state frontal, frontlateral, and parietal alpha asymmetry:A pilot study examining relations with depressive disorder type and severity.Frontiers in psychology · 2023Article
- High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia.Journal of personalized medicine · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElectroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.
methodsWe recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4-F3, F8-F7, FP2-FP1, AF4-AF3, F6-F5, and F2-F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.
resultsPatients with schizophrenia showed significantly lower left FAA than healthy controls (F4-F3, schizophrenia vs. healthy controls: - 0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.
conclusionsThe present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.
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