Evidence map›Paper›PMID 33302904›Full record

ArticleBMC ophthalmology2020

Increased Association of Deamidated αA-

Om Srivastava, Kiran Srivastava, Roy Joseph, Landon Wilson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Om SrivastavaDepartment of Optometry and Vision Science, University of Alabama at Birmingham, 1716, University Boulevard, Birmingham, AL, 35294-0010, USA. srivasta@uab.edu.ORCID http://orcid.org/0000-0001-5727-4801
Kiran SrivastavaDepartment of Optometry and Vision Science, University of Alabama at Birmingham, 1716, University Boulevard, Birmingham, AL, 35294-0010, USA.
Roy JosephDepartment of Optometry and Vision Science, University of Alabama at Birmingham, 1716, University Boulevard, Birmingham, AL, 35294-0010, USA.
Landon WilsonTargeted Metabolomics and Proteomics Laboratory (TMPL), Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, 35294-0010, USA.
University of Alabama at Birmingham · USTarget (United States) · US

Funding

PROTEINASE INHIBITORS &CRYSTALLIN FRAGMENTS IN CATARACTR01EY006400 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SRIVASTAVA, OM PRAKASH · 1985 to 2018
$5.6M
Molecular Mechanism of αAN101D-Transgene-Induced Age-Related CataractR01EY031303 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SRIVASTAVA, OM PRAKASH · 2020 to 2023
$1.6M
NEI NIH HHS EY06400NEI NIH HHS R01 EY006400NEI NIH HHS R01 EY031303
6 · The paper itself

Abstract

We have generated two mouse models, in one by inserting the human lens αAN101D transgene in CRYαA

methodsLenses of varying ages from CRYαA

resultsCompared to the lenses of CRYαA

conclusionsThe results show that an increased lens membrane association of αA

Indexed as

CataractCrystallinsLens, CrystallineAnimalsAnimals, Genetically ModifiedBlotting, WesternDisease Models, AnimalMiceMice, TransgenicCrystallinsCataractCrystallinsDeamidationLensPost-translational modificationsTransgenic mice

Identifiers

PMID33302904
PMCPMC7726915
OpenAlexW3111474966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.