Evidence map›Paper›PMID 33302787›Full record

ReviewRNA biology2021

Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells.

Yiwei Zhang, Zhiyuan Wei, Hui Dong, Jian Zhou, Jizhao Yuan, Bing Ni, Yuzhang Wu, Chao Han, Yi Tian

Open access · bronzeAbstract readReview
In one paragraph

Review in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
  5. Review
  6. Modulation of miRISC-Mediated Gene Silencing in Eukaryotes.Frontiers in molecular biosciences · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yiwei ZhangInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Zhiyuan WeiDepartment of Orthopedics, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, PR China.ORCID 0000-0002-8795-6878
Hui DongInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Jian ZhouInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Jizhao YuanInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Bing NiDepartment of Pathophysiology, Third Military Medical University (Army Medical University), Chongqing, PR China.
Yuzhang WuInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Chao HanInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Yi TianInstitute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Th17 cells remain one of the most important subsets of T cells in numerous autoimmune and chronic inflammatory diseases. Posttranscriptional regulation (PTR), especially mRNA stability, has recently emerged as an important mechanism that controls the fate of Th17 cells. This review summarizes the current knowledge on RNA-binding proteins (RBPs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that induce mRNA stability changes and their roles in mediating the differentiation, proliferation, function, and migration of Th17 cells. In addition, we summarize the role of RNA modifications and nonsense-mediated mRNA decay (NMD) in Th17 cells. Ongoing research will help to identify practical applications for the regulation of mRNA stability and provide potential targets to prevent and treat Th17-related autoimmune diseases.

Indexed as

AnimalsAutoimmune DiseasesHumansRNA-Binding ProteinsRNA, Long NoncodingRNA, MessengerRNA StabilityTh17 CellsRNA-Binding ProteinsRNA, Long NoncodingRNA, MessengerdecaylncRNAsmiRNAsmRNA stabilitynmdpathogenicityrbpsrna modificationsTh17

Identifiers

PMID33302787
PMCPMC8078524
OpenAlexW3111666075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.