Evidence map›Paper›PMID 33302699›Full record

ArticleJournal of evidence-based integrative medicine

Anti-Proliferative and Pro-Apoptotic Effects of

Zeyad Alehaideb, Saleh AlGhamdi, Wesam Bin Yahya, Hamad Al-Eidi, Mashael Alharbi, Monira Alaujan, Abeer Albaz, Muruj Tukruni, Atef Nehdi, Maha-Hamadien Abdulla and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of evidence-based integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Protective Effects ofFood science & nutrition · 2025
    Article
  2. Review
  3. ExploringSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  4. Article
  5. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Molecules (Basel, Switzerland) · 2022
    Article
  8. Apoptosis-mediated anti-proliferative activity ofFrontiers in cell and developmental biology · 2022
    Article
  9. Article
  10. Article
  11. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zeyad AlehaidebCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Saleh AlGhamdiKing Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Wesam Bin YahyaCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Hamad Al-EidiCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Mashael AlharbiCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Monira AlaujanCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Abeer AlbazCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID 0000-0002-1098-8652
Muruj TukruniCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Atef NehdiKing Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Maha-Hamadien AbdullaDepartment of Surgery, King Khalid University Hospital and College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Sabine Matou-NasriCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID 0000-0003-4372-2903
King Saud bin Abdulaziz University for Health Sciences · SAKing Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC), the most aggressive subtype, does not respond to targeted therapy due to the lack of hormone receptors. There is an urgent need for alternative therapies, including natural product-based anti-cancer drugs, at lower cost. We investigated the impact of a

Indexed as

PhytotherapyPolygonaceaeTriple Negative Breast NeoplasmsAntineoplastic Agents, PhytogenicApoptosisCaspase 3CatalaseCell CycleCell Cycle CheckpointsCell Line, TumorCell ProliferationCell SurvivalCyclin-Dependent Kinase Inhibitor p21Cytochromes cHumansMembrane Potential, MitochondrialAntineoplastic Agents, PhytogenicCaspase 3CatalaseCyclin-Dependent Kinase Inhibitor p21Cytochromes cPlant ExtractsReactive Oxygen SpeciesapoptosisCalligonum comosumcell cyclenatural productsreactive oxygen speciestriple-negative breast cancer

Identifiers

PMID33302699
PMCPMC7734547
OpenAlexW3111503055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.