Evidence map›Paper›PMID 33302582›Full record

ReviewInternational journal of molecular sciences2020

Light Pollution and Cancer.

William H Walker, Jacob R Bumgarner, James C Walton, Jennifer A Liu, O Hecmarie Meléndez-Fernández, Randy J Nelson, A Courtney DeVries

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  20. Melatonin: A Potential Regulator of DNA Methylation.Antioxidants (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

William H WalkerDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0001-6209-5015
Jacob R BumgarnerDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-0387-9263
James C WaltonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-3049-1029
Jennifer A LiuDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
O Hecmarie Meléndez-FernándezDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
Randy J NelsonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-8194-4016
A Courtney DeVriesDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Stroke and Alzheimers Disease Related DementiasT32AG052375 · NIA · WEST VIRGINIA UNIVERSITY · PI Paul D Chantler, BERNARD G. SCHREURS · 2017 to 2026
$3.5M
Adverse Consequences of Light at Night for Cerebral IschemiaR01NS092388 · NINDS · WEST VIRGINIA UNIVERSITY · PI DEVRIES, ANNE COURTNEY, NELSON, RANDY J. · 2015 to 2019
$2.3M
Circulating plasma tumor DNA as a biomarker for early stage breast cancerR01CA194024 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO · 2016 to 2020
$1.9M
NCI NIH HHS R01CA194024NIA NIH HHS T32 AG052375NIGMS NIH HHS 5U54GM104942-03NIGMS NIH HHS U54 GM104942NINDS NIH HHS R01NS092388
6 · The paper itself

Abstract

For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metabolic disorders, and mood disorders. Within this review, we present a brief overview of the molecular circadian clock system and the importance of maintaining fidelity to bright days and dark nights. We describe the interrelation between core clock genes and the cell cycle, as well as the contribution of clock genes to oncogenesis. Next, we review the clinical implications of disrupted circadian rhythms on cancer, followed by a section on the foundational science literature on the effects of light at night and cancer. Finally, we provide some strategies for mitigation of disrupted circadian rhythms to improve health.

Indexed as

Circadian RhythmAnimalsCarcinogenesisCircadian Rhythm Signaling Peptides and ProteinsHumansNeoplasmsShift Work ScheduleCircadian Rhythm Signaling Peptides and Proteinscancercell cyclecircadian rhythmsclock geneslight at night

Identifiers

PMID33302582
PMCPMC7764771
OpenAlexW3113269837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.