Evidence map›Paper›PMID 33302527›Full record

ArticlePharmaceutics2020

Sustained Calcium(II)-Release to Impart Bioactivity in Hybrid Glass Scaffolds for Bone Tissue Engineering.

Dzmitry Kuzmenka, Claudia Sewohl, Andreas König, Tobias Flath, Sebastian Hahnel, Fritz Peter Schulze, Michael C Hacker, Michaela Schulz-Siegmund

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dzmitry KuzmenkaPharmaceutical Technology, Institute of Pharmacy, Faculty of Medicine, Leipzig University, 04317 Leipzig, Germany.
Claudia SewohlPharmaceutical Technology, Institute of Pharmacy, Faculty of Medicine, Leipzig University, 04317 Leipzig, Germany.
Andreas KönigDepartment of Prosthetic Dentistry and Dental Materials Science, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-5617-3707
Tobias FlathDepartment of Mechanical and Energy Engineering, University of Applied Sciences Leipzig, 04277 Leipzig, Germany.
Sebastian HahnelDepartment of Prosthetic Dentistry and Dental Materials Science, Leipzig University, 04103 Leipzig, Germany.
Fritz Peter SchulzeDepartment of Mechanical and Energy Engineering, University of Applied Sciences Leipzig, 04277 Leipzig, Germany.
Michael C HackerPharmaceutical Technology, Institute of Pharmacy, Faculty of Medicine, Leipzig University, 04317 Leipzig, Germany.
Michaela Schulz-SiegmundPharmaceutical Technology, Institute of Pharmacy, Faculty of Medicine, Leipzig University, 04317 Leipzig, Germany.
Leipzig University · DELeipzig University of Applied Sciences · DEHeinrich Heine University Düsseldorf · DE

Funding

Deutsche Forschungsgemeinschaft 59307082-TRR67
6 · The paper itself

Abstract

In this study, we integrated different calcium sources into sol-gel hybrid glass scaffolds with the aim of producing implants with long-lasting calcium release while maintaining mechanical strength of the implant. Calcium(II)-release was used to introduce bioactivity to the material and eventually support implant integration into a bone tissue defect. Tetraethyl orthosilicate (TEOS) derived silica sols were cross-linked with an ethoxysilylated 4-armed macromer, pentaerythritol ethoxylate and processed into macroporous scaffolds with defined pore structure by indirect rapid prototyping. Triethyl phosphate (TEP) was shown to function as silica sol solvent. In a first approach, we investigated the integration of 1 to 10% CaCl

Indexed as

bioactivitybone tissue engineeringCalcium(II) releasehybrid glass scaffoldssol-gel

Identifiers

PMID33302527
PMCPMC7764395
OpenAlexW3112280545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.