Evidence map›Paper›PMID 33302448›Full record

ArticleMetabolites2020

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics.

Holden C Williams, Margaret A Piron, Grant K Nation, Adeline E Walsh, Lyndsay E A Young, Ramon C Sun, Lance A Johnson

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Microbiome · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Cell reports methods · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Holden C WilliamsDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Margaret A PironDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Grant K NationDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Adeline E WalshDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Lyndsay E A YoungDepartment of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA.ORCID 0000-0002-6873-5674
Ramon C SunSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA.ORCID 0000-0002-3009-1850
Lance A JohnsonDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.ORCID 0000-0003-0134-7586
University of Kentucky · US

Funding

APOE and the PPP: Glucose Metabolism and Oxidative Stress in Alzheimer's DiseaseR01AG060056 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2018 to 2022
$2.5M
Examining the Effects of the Neuroprotective APOE2 Allele on Peripheral ImmunometabolismR01AG062550 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2019 to 2023
$2.2M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG057461 · NIA · UNIVERSITY OF KENTUCKY · PI MURPHY, MICHAEL PAUL, VAN ELDIK, LINDA J · 2017 to 2021
$2.1M
Aberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's DiseaseR01AG066653 · NIA · UNIVERSITY OF KENTUCKY · PI SUN, RAMON C. · 2020 to 2024
$1.9M
Markey Cancer Center, University of Kentucky P30CA177558NIA NIH HHS R01 AG060056NIA NIH HHS R01 AG062550NIA NIH HHS R01 AG066653NIA NIH HHS T32 AG057461NIH HHS 1R01AG060056NIH HHS 1T32AG057461NIH HHS R01AG062550NIH HHS R01AG066653Rally Foundation Independent Investigator GrantSt. Baldrick's Foundation Career Development Award
6 · The paper itself

Abstract

Stable isotope-resolved metabolomics (SIRM) is a powerful tool for understanding disease. Advances in SIRM techniques have improved isotopic delivery and expanded the workflow from exclusively in vitro applications to in vivo methodologies to study systemic metabolism. Here, we report a simple, minimally-invasive and cost-effective method of tracer delivery to study SIRM in vivo in laboratory mice. Following a brief fasting period, we orally administered a solution of [U-

Indexed as

13C-glucoseAlzheimer’s diseasebrain metabolismdiabetesgavagemetabolomicsSIRMstable isotope

Identifiers

PMID33302448
PMCPMC7764755
OpenAlexW3111323821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.