ReviewPathogens (Basel, Switzerland)2020
Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2.
Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Trial
- Impact of SARS-CoV-2 infection history on the clinical features and outcomes of patients with recurrent pulmonary tuberculosis: a retrospective case-control study.Annals of medicine · 2026Article
- Individuals with latent tuberculosis in a high TB endemic country show mild COVID-19.PloS one · 2025Article
- Chordoma Spontaneous Regression After COVID-19.Viruses · 2024Article
- COVID-19: from immune response to clinical intervention.Precision clinical medicine · 2024Review
- Modulation of cyclophosphamide-induced immunosuppression and intestinal flora in broiler by deep eutectic solvent extracted polysaccharides ofFrontiers in veterinary science · 2024Article
- Mucosal immunity in COVID-19: a comprehensive review.Frontiers in immunology · 2024Review
- New-onset aplastic anemia after SARS-CoV-2 vaccination.International journal of hematology · 2023Review
- Article
- Immune responses in mildly versus critically ill COVID-19 patients.Frontiers in immunology · 2023Review
- Heterogenous CD8+ T Cell Maturation and 'Polarization' in Acute and Convalescent COVID-19 Patients.Viruses · 2022Article
- The role of antigen-presenting cells in the pathogenesis of COVID-19.Pathology, research and practice · 2022Review
- Computer Aided Drug Design Approach to Screen Phytoconstituents ofLife (Basel, Switzerland) · 2022Article
- Mechanistic Insights Into the Immune Pathophysiology of COVID-19; An In-Depth Review.Frontiers in immunology · 2022Review
- Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives.Frontiers in immunology · 2022Review
- An update on host immunity correlates and prospects of re-infection in COVID-19.International reviews of immunology · 2022Review
- COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank.BMC medicine · 2021Article
- SARS-CoV-2-specific immune response in COVID-19 convalescent individuals.Signal transduction and targeted therapy · 2021Article
- Article
- Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis.Cell death & disease · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December 2019 in China, and has led to thousands of mortalities globally each day. While the innate immune response serves as the first line of defense, viral clearance requires activation of adaptive immunity, which employs B and T cells to provide sanitizing immunity. SARS-CoV-2 has a potent arsenal of mechanisms used to counter this adaptive immune response through processes, such as T cells depletion and T cell exhaustion. These phenomena are most often observed in severe SARS-CoV-2 patients, pointing towards a link between T cell function and disease severity. Moreover, neutralizing antibody titers and memory B cell responses may be short lived in many SARS-CoV-2 patients, potentially exposing these patients to re-infection. In this review, we discuss our current understanding of B and T cells immune responses and activity in SARS-CoV-2 pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.