Evidence map›Paper›PMID 33302352›Full record

ArticleNutrients2020

Expression of Telomeric Repeat-Containing RNA Decreases in Sarcopenia and Increases after Exercise and Nutrition Intervention.

Ke-Vin Chang, Yu-Chen Chen, Wei-Ting Wu, Hong-Jhin Shen, Kuo-Chin Huang, Hsueh-Ping Chu, Der-Sheng Han

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05772910 (Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05772910 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.

TypeinterventionalSponsorUniversity of CadizRan2024 to 2026Enrolled110ConditionsFrailty, Disability Physical, Old Age, AtrophyArmsEDUcation, EXERcise, EDU-EXER, CONtrol
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ke-Vin ChangDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei 100, Taiwan.ORCID 0000-0002-7558-5651
Yu-Chen ChenInstitute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan.
Wei-Ting WuDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei 100, Taiwan.
Hong-Jhin ShenInstitute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan.
Kuo-Chin HuangCommunity and Geriatric Medicine Research Center, National Taiwan University Hospital, Bei-Hu Branch, Taipei 108, Taiwan.ORCID 0000-0002-6029-5520
Hsueh-Ping ChuInstitute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan.
Der-Sheng HanDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei 100, Taiwan.ORCID 0000-0001-7642-8060
National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology 107-2314-B-002 -047 -MY3, 108-2321-B-001 -005 -, 107-2321-B-001-020 -, 106-2321-B-001-044
6 · The paper itself

Abstract

Sarcopenia is defined as aging-related loss of muscle mass and function. Telomere length in chromosomes shortens with age and is modulated by telomeric repeat-containing RNA (TERRA). This study aimed to explore the impact of aging and sarcopenia on telomere length and TERRA expression, and changes following strengthening exercise and nutrition intervention (supplement of branched-chain amino acids, calcium and vitamin D3) for 12 weeks in the sarcopenic population. Older adults (≥65 years old) were divided into non-sarcopenic controls (

Indexed as

ExerciseAgedAgingBiomarkersBody CompositionDietary SupplementsDNA-Binding ProteinsExercise TherapyFemaleGene Expression RegulationHeLa CellsHumansMaleMuscle, SkeletalMuscle StrengthNutritional StatusBiomarkersDMRT2 protein, humanDNA-Binding ProteinsRNATranscription FactorsexercisenutritionsarcopeniatelomereTERRA

Identifiers

PMID33302352
PMCPMC7762552
OpenAlexW3111417755

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.