Evidence map›Paper›PMID 33302221›Full record

ArticleGait & posture2021

Does gait bout definition influence the ability to discriminate gait quality between people with and without multiple sclerosis during daily life?

Vrutangkumar V Shah, James McNames, Graham Harker, Carolin Curtze, Patricia Carlson-Kuhta, Rebecca I Spain, Mahmoud El-Gohary, Martina Mancini, Fay B Horak

Open access · greenAbstract read
In one paragraph

Article in Gait & posture, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Continuous Monitoring of Head Turns: Compliance, Kinematics, and Reliability of Wearable Sensing.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Vrutangkumar V ShahDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA. Electronic address: shahvr@ohsu.edu.
James McNamesDepartment of Electrical and Computer Engineering, Portland State University, Portland, OR, USA; APDM, Inc., Portland, OR, USA.
Graham HarkerDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Carolin CurtzeDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA.
Patricia Carlson-KuhtaDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Rebecca I SpainDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA; Veterans Affairs Portland Health Care System, Portland, OR, USA.
Mahmoud El-GoharyAPDM, Inc., Portland, OR, USA.
Martina ManciniDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Fay B HorakDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA; APDM, Inc., Portland, OR, USA.
Oregon Health & Science University · USPortland State University · USUniversity of Nebraska at Omaha · USVA Portland Health Care System · US

Funding

Mobility Life: Monitoring Mobility in Daily Lives of People with Neurological DiseaseR44AG055388 · NIA · APDM, INC. · PI EL-GOHARY, MAHMOUD, HORAK, FAY BAHLING · 2016 to 2019
$2.9M
NIA NIH HHS R44 AG055388
6 · The paper itself

Abstract

backgroundThere is currently no consensus about standardized gait bout definitions when passively monitoring walking during normal daily life activities. It is also not known how different definitions of a gait bout in daily life monitoring affects the ability to distinguish pathological gait quality. Specifically, how many seconds of a pause with no walking indicates an end to one gait bout and the start of another bout? In this study, we investigated the effect of 3 gait bout definitions on the discriminative ability to distinguish quality of walking in people with multiple sclerosis (MS) from healthy control subjects (HC) during a week of daily living.

methods15 subjects with MS and 16 HC wore instrumented socks on each foot and one Opal sensor over the lower lumbar area for a week of daily activities for at least 8 h/day. Three gait bout definitions were based on the length of the pause between the end of one gait bout and start of another bout (1.25 s, 2.50 s, and 5.0 s pause). Area under the curve (AUC) was used to compare gait quality measures in MS versus HC.

resultsTotal number of gait bouts over the week were statistically significantly different across bout definitions, as expected. However, AUCs of gait quality measures (such as gait speed, stride length, stride time) discriminating people with MS from HC were not different despite the 3 bout definitions. SIGNIFICANCE: Quality of gait measures that discriminate MS from HC during daily life are not influenced by the length of a gait bout, despite large differences in quantity of gait across bout definitions. Thus, gait quality measures in people with MS versus controls can be compared across studies using different gait bout definitions with pause lengths ≤5 s.

Indexed as

FemaleGaitHumansMaleMiddle AgedMultiple SclerosisQuality of LifeBoutFree-livingGaitMultiple sclerosisWearable sensors

Identifiers

PMID33302221
PMCPMC7946343
OpenAlexW3107225396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.