Evidence map›Paper›PMID 33302179›Full record

ArticleNeurobiology of aging2021

The role of cap-dependent translation in aged-related changes in neuroimmunity and affective behaviors.

Prapti H Mody, Natalia Lucia Dos Santos, Melissa E Lenert, Luz R Barron, Bethany A Nottingham, Michael D Burton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Prapti H ModyDepartment of Neuroscience, Neuroimmunology and Behavior Laboratory, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Natalia Lucia Dos SantosDepartment of Neuroscience, Neuroimmunology and Behavior Laboratory, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Melissa E LenertDepartment of Neuroscience, Neuroimmunology and Behavior Laboratory, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Luz R BarronDepartment of Neuroscience, Neuroimmunology and Behavior Laboratory, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Bethany A NottinghamDepartment of Neuroscience, Neuroimmunology and Behavior Laboratory, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
Michael D BurtonDepartment of Neuroscience, Neuroimmunology and Behavior Laboratory, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA. Electronic address: michael.burton@utdallas.edu.
The University of Texas at Dallas · US

Funding

Mechanisms involved in postoperative recovery: a focus on pain, delirium, and neuroinflammationR35GM147094 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Michael D Burton · 2022 to 2026
$1.9M
The Role of Cell-specific TLR-4 Signaling in Developing Chronic PainK22NS096030 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI BURTON, MICHAEL D · 2016 to 2019
$838k
NIGMS NIH HHS R35 GM147094NINDS NIH HHS K22 NS096030
6 · The paper itself

Abstract

Translation regulation in the context of aged-associated inflammation and behavioral impairments is not well characterized. Aged individuals experience lower life quality due to behavioral impairments. In this study, we used young and aged transgenic mice that are unable to activate the cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E) to examine the role of protein translation control in aging, memory, depression, and anxiety. To determine how products of cap-dependent translation play a permissive role in aged-associated inflammation, we assessed levels of pro-inflammatory cytokines in various brain regions involved in the above-mentioned behaviors. We found that functional eIF4E is not necessary for age-related deficits in spatial and short-term memory but is important for depressive and anxiety-like behavior and this is correlated with pro-inflammatory cytokines in discrete brain regions. Thus, we have begun to elucidate a role for eIF4E phosphorylation in the context of aged-related behavioral impairments and chronic low-grade inflammation that may help identify novel immune modulators for therapeutic targets and decrease the burden of self-care among the geriatric population.

Indexed as

AffectAgingAnimalsAnxietyBrainCytokinesDepressionEukaryotic Initiation Factor-4EInflammationInflammation MediatorsMice, TransgenicPhosphorylationProtein BiosynthesisRNA Cap-Binding ProteinsCytokineseIF4E protein, mouseEukaryotic Initiation Factor-4EInflammation MediatorsRNA Cap-Binding ProteinsAgingAnxietyCognitionDepressioneIF4EInflammation

Identifiers

PMID33302179
PMCPMC7870568
OpenAlexW3106505858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.