ArticleBiomaterials2021
Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment.
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Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 110 citations in OpenAlex.
- Demystifying Nanotherapeutic Modalities: Unravelling the Mysteries from Antibiofilm Mechanisms to Regenerative and Clinical Translation.Biomedicines · 2026Review
- Near infrared light enhanced a green vitamin Cu/Co@MOF laccase-like nanozyme activity for estrogen colorimetric detection.Mikrochimica acta · 2026Article
- Peroxidase-mimicking chitosan/dextran-coated cobalt ferrite-graphene oxide nanozyme enhances hydrogen peroxide-mediated killing of cariogenic pathogens in dental biofilm models.Scientific reports · 2026Article
- Nanozyme Microrobots: Programmable Spatiotemporal Catalysis for Targeted Therapy and Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy.Journal of nanobiotechnology · 2026Review
- Antimicrobial Nanozymes: Structure-Activity-Guided Design, Synergy, and Applications.Research (Washington, D.C.) · 2026Review
- Flower-like ferro-polydopamine nanozymes with peroxidase-like activity for early caries prevention.Frontiers in microbiology · 2026Article
- Development of a fast-crosslinking hydrogel system doped with magnetic mesoporous nanoparticles for sustained fluoride ion release and caries prevention.Frontiers in bioengineering and biotechnology · 2026Article
- pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Complete genome sequence ofMicrobiology resource announcements · 2025Article
- Emerging green-synthesized nanozymes for microbial applications: toward sustainable antimicrobial technologies.World journal of microbiology & biotechnology · 2025Review
- Nanotherapies Based on ROS Regulation in Oral Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy?International journal of molecular sciences · 2025Review
- Nanozymes: a promising solution for dental antibacterial applications.RSC advances · 2024Review
- Microrobotics in endodontics: A perspective.International endodontic journal · 2024Review
- The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis.Journal of nanobiotechnology · 2024Review
- Nanozyme-Based Robotics Approach for Targeting Fungal Infection.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Fingolimod Inhibits Exopolysaccharide Production and Regulates Relevant Genes to Eliminate the Biofilm ofInternational journal of molecular sciences · 2024Article
- Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases.RSC advances · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 3 countries.
Yue HuangDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Yuan LiuBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Shrey ShahDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Dongyeop KimBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Preventive Dentistry, School of Dentistry, Jeonbuk National Universitys, Deokjin-gu, Jeonju, 54896, South Korea.
Aurea Simon-SoroBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Tatsuro ItoBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Pediatric Dentistry, School of Dentistry at Matsudo, Nihon University, Matsudo, Chiba, 271-8587, Japan.
Maryam HajfathalianDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Yong LiBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Jessica C HsuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Lenitza M NievesDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Faizan AlawiDepartment of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19014, United States.
Pratap C NahaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
David P CormodeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Cardiology, University of Pennsylvania, Philadelphia, PA, 19104, United States; Center for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104, United States. Electronic address: david.cormode@pennmedicine.upenn.edu.
Hyun KooBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States; Center for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104, United States. Electronic address: koohy@upenn.edu.
University of Pennsylvania · USCenter for Innovation · USNihon University · JP
Funding
Biofilm Elimination and Caries Prevention using Multifunctional NanocatalystsR01DE025848 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2017 to 2025
$5.6MNIDCR NIH HHS R01 DE025848
Abstract
Human dental caries is an intractable biofilm-associated disease caused by microbial interactions and dietary sugars on the host's teeth. Commensal bacteria help control opportunistic pathogens via bioactive products such as hydrogen peroxide (H
Indexed as
Dental CariesHydrogen PeroxideBiofilmsHumansMicrobial InteractionsStreptococcus mutansHydrogen PeroxideBiofilmCatalytic nanoparticlesDental cariesGlucose oxidaseHybrid nanozymePolymicrobial
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.