Evidence map›Paper›PMID 33302097›Full record

ArticlePsychiatry research. Neuroimaging2021

An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder.

Gwyneth Zai, Paul D Arnold, Margaret A Richter, Gregory L Hanna, David Rosenberg, James L Kennedy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Gwyneth ZaiTanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: gwyneth.zai@camh.ca.
Paul D ArnoldThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, AB T2N 4N1, Canada; Program in Genetics and Genomic Biology and Department of Psychiatry, The Hospital for Sick Children, Toronto ON M5G 1 × 8, Canada.
Margaret A RichterDepartment of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Frederick W. Thompson Anxiety Disorders Centre, Department of Psychiatry, Sunnybrook Health Science Centre, Toronto ON M4N 3M5, Canada.
Gregory L HannaDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, United States.
David RosenbergDepartment of Psychiatry & Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, United States.
James L KennedyTanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
University of Toronto · CASunnybrook Health Science Centre · CAUniversity of Calgary · CAUniversity of Michigan–Ann Arbor · USWayne State University · US

Funding

Multimodal Investigation of Excitatory/Inhibitory Imbalances and Network Dysfunction Related to Motor Control in OCD Youth: ¹H fMRS and fMRI ApplicationsR01MH059299 · NIMH · WAYNE STATE UNIVERSITY · PI DIWADKAR, VAIBHAV A., ROSENBERG, DAVID R · 1999 to 2025
$11.1M
Action Monitoring and Genomic Variants in Pediatric Obsessive-Compulsive BehaviorR01MH101493 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARNOLD, PAUL DANIEL, GEHRING, WILLIAM J · 2013 to 2016
$2.3M
PEDIATRIC OBSESSIVE COMPULSIVE DISORDERK24MH002037 · NIMH · WAYNE STATE UNIVERSITY · PI ROSENBERG, DAVID R · 2001 to 2010
$1.5M
3/3 Brain Function and Genetics in Pediatric Obsessive-Compulsive BehaviorsR01MH085300 · NIMH · UNIVERSITY OF CALGARY · PI ARNOLD, PAUL DANIEL, SCHERER, STEPHEN W. · 2009 to 2019
$956k
CIHR MOP-38077NIMH NIH HHS K24 MH002037NIMH NIH HHS R01 MH059299NIMH NIH HHS R01 MH085300NIMH NIH HHS R01 MH101493
6 · The paper itself

Abstract

An increasing number of neuroimaging studies have implicated alterations of white matter in obsessive-compulsive disorder (OCD). The myelin oligodendrocyte glycoprotein (MOG) gene plays a major role in myelination, and has previously demonstrated significant association with this disorder, thus variations in this gene may contribute to observed white matter alterations. The purpose of this study is to examine the relationship between white matter volume in OCD and genetic variations in the MOG gene. Two polymorphisms in the MOG gene, MOG(C1334T) and MOG(C10991T), were investigated for association with total white matter volume as measured using volumetric magnetic resonance imaging in 37 pediatric OCD patients. We compared white matter volumes between allele and genotype groups for each polymorphism using ANCOVA. A significant relationship was detected between genotype C/C of MOG(C10991T) and decreased total white matter volume (P = 0.016). Our results showed an association between a MOG genetic variant and white matter volume. This finding is intriguing in light of the posited role of white matter alteration in the etiology of at least some cases of childhood-onset OCD. Further investigation with larger samples and sub-regional white matter volume phenotypes is warranted.

Indexed as

Obsessive-Compulsive DisorderWhite MatterChildHumansMagnetic Resonance ImagingMyelin-Oligodendrocyte GlycoproteinPolymorphism, GeneticMOG protein, humanMyelin-Oligodendrocyte GlycoproteinGeneticsMagnetic resonance imaging (MRI)Myelin oligodendrocyte glycoprotein (MOG) genePediatric obsessive-compulsive disorder (OCD)White matter volume

Identifiers

PMID33302097
PMCPMC7775903
OpenAlexW3110577607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.