Observational studyClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021
Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation.
Observational study in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Neuroimaging correlates of post-stroke fatigue: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2026Article
- Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Increased neural responsiveness to distractors irrespective of perceptual load explains attention deficit in post-stroke fatigue.Journal of neuropsychology · 2026Article
- Stratification algorithm for repetitive TMS in stroke (START): Results from an exploratory crossover study.Journal of the neurological sciences · 2025Article
- Post-stroke fatigue - a multidimensional problem or a cluster of disorders? A case for phenotyping post-stroke fatigue.The Journal of physiology · 2025Review
- Behavioral and Neural correlates of Post-STROKE Fatigue: A randomized controlled trial protocol.PloS one · 2025Article
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2024Article
- Influence of Perceptual Load on Attentional Orienting in Post-Stroke Fatigue: A Study of Auditory Evoked Potentials.Neurorehabilitation and neural repair · 2024Observational
- Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Review
- The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability.Clinical neurophysiology practice · 2024Review
- Electroencephalography-Derived Functional Connectivity in Sensorimotor Networks in Post Stroke Fatigue.Brain topography · 2023Article
- The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- "I Give It Everything for an Hour Then I Sleep for Four." The Experience of Post-stroke Fatigue During Outpatient Rehabilitation Including the Perspectives of Carers: A Qualitative Study.Frontiers in neurology · 2022Article
- Changes in Corticospinal Circuits During Premovement Facilitation in Physiological Conditions.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesReduced corticospinal excitability at rest is associated with post-stroke fatigue (PSF). However, it is not known if corticospinal excitability prior to a movement is also altered in fatigue which may then influence subsequent behaviour. We hypothesized that the levels of PSF can be explained by differences in modulation of corticospinal excitability during movement preparation.
methods73 stroke survivors performed an auditory reaction time task. Corticospinal excitability was measured using transcranial magnetic stimulation. Fatigue was quantified using the fatigue severity scale. The effect of time and fatigue on corticospinal excitability and reaction time was analysed using a mixed effects model.
resultsThose with greater levels of PSF showed reduced suppression of corticospinal excitability during movement preparation and increased facilitation immediately prior to movement onset (β = -0.0066, t = -2.22, p = 0.0263). Greater the fatigue, slower the reaction times the closer the stimulation time to movement onset (β = 0.0024, t = 2.47, p = 0.0159).
conclusionsLack of pre-movement modulation of corticospinal excitability in high fatigue may indicate poor sensory processing supporting the sensory attenuation model of fatigue. SIGNIFICANCE: We take a systems-based approach and investigate the motor system and its role in pathological fatigue allowing us to move towards gaining a mechanistic understanding of chronic pathological fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.