Evidence map›Paper›PMID 33302058›Full record

ArticleDifferentiation; research in biological diversity

Gestational folate deficiency alters embryonic gene expression and cell function.

R S Seelan, P Mukhopadhyay, J Philipose, R M Greene, M M Pisano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Anencephaly and Severe Myelodysplasia in a Stillborn Brown Bear (Animals : an open access journal from MDPI · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

R S SeelanDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development & Anomalies, University of Louisville Dental School, 501 S. Preston St., Louisville, KY, 40292, USA.
P MukhopadhyayDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development & Anomalies, University of Louisville Dental School, 501 S. Preston St., Louisville, KY, 40292, USA.
J PhiliposeDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development & Anomalies, University of Louisville Dental School, 501 S. Preston St., Louisville, KY, 40292, USA.
R M GreeneDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development & Anomalies, University of Louisville Dental School, 501 S. Preston St., Louisville, KY, 40292, USA. Electronic address: dr.bob.greene@gmail.com.
M M PisanoDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development & Anomalies, University of Louisville Dental School, 501 S. Preston St., Louisville, KY, 40292, USA.
University of Louisville · US

Funding

U-SHAPED DEVELOPMENT IN INFANT COGNITION AND PERCEPTIONP20RR017702 · NCRR · UNIVERSITY OF LOUISVILLE · PI SEELAN, RATNAM SATHIAGANA · 2002 to 2011
$15.0M
Transcriptional Coactivators and Pregnancy OutcomesR01HD053509 · NICHD · UNIVERSITY OF LOUISVILLE · PI GREENE, ROBERT M · 2008 to 2012
$1.5M
NUTRITIONAL EPIGENETICS AND OROFACIAL DEVELOPMENTR01DE018215 · NIDCR · UNIVERSITY OF LOUISVILLE · PI GREENE, ROBERT M · 2008 to 2011
$1.3M
NCRR NIH HHS P20 RR017702NICHD NIH HHS R01 HD053509NIDCR NIH HHS R01 DE018215
6 · The paper itself

Abstract

Folic acid is a nutrient essential for embryonic development. Folate deficiency can cause embryonic lethality or neural tube defects and orofacial anomalies. Folate receptor 1 (Folr1) is a folate binding protein that facilitates the cellular uptake of dietary folate. To better understand the biological processes affected by folate deficiency, gene expression profiles of gestational day 9.5 (gd9.5) Folr1

Indexed as

Cell DifferentiationGene Expression Regulation, DevelopmentalAnimalsEmbryo, MammalianFemaleFolate Receptor 1Folic AcidGene Expression ProfilingGestational AgeMaleMiceMice, Inbred C57BLMice, KnockoutNeural CrestNeural Tube DefectsFolate Receptor 1Folic AcidFolr1 protein, mouseApoptosisCell migrationF-actinFolr1Neural crest cellsProliferation

Identifiers

PMID33302058
PMCPMC7855679
OpenAlexW3106615577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.