Evidence map›Paper›PMID 33301871›Full record

ArticleBrain, behavior, and immunity2021

Inflammatory cytokine levels implicated in Alzheimer's disease moderate the effects of sex on verbal memory performance.

Jessica Z K Caldwell, Jefferson W Kinney, Aaron Ritter, Arnold Salazar, Christina G Wong, Dietmar Cordes, George M Slavich

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Intersectionality in Alzheimer's Disease: The Role of Female Sex and Black American Race in the Development and Prevalence of Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jessica Z K CaldwellCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA. Electronic address: caldwej5@ccf.org.
Jefferson W KinneyDepartment of Brain Health, University of Nevada, Las Vegas, NV, USA.
Aaron RitterCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Arnold SalazarDepartment of Brain Health, University of Nevada, Las Vegas, NV, USA.
Christina G WongCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Dietmar CordesCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
George M SlavichCousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Cleveland Clinic · USUniversity of Nevada, Las Vegas · USUniversity of California, Los Angeles · US

Funding

Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
NVEDARC Clinical CoreP20AG068053 · NIA · CLEVELAND CLINIC FOUNDATION · PI FOX, ROBERT J. · 2020 to 2022
$3.3M
Machine and deep learning for finding multimodal imaging biomarkers in prodromal ADRF1AG071566 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI CORDES, DIETMAR, LOWE, MARK J · 2021 to 2021
$2.3M
Interactions of Sex and Gender Factors in Risk for Alzheimers Disease: Links Between Stress, Neural Activity, Inflammation, and MemoryR01AG074392 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRKLAND CALDWELL, JESSICA · 2021 to 2024
$1.8M
Neural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772k
NIA NIH HHS P20 AG068053NIA NIH HHS R01 AG074392NIA NIH HHS RF1 AG071566NIGMS NIH HHS P20 GM109025NIMH NIH HHS K08 MH103443
6 · The paper itself

Abstract

Despite having an initial verbal memory advantage over men, women have greater rates of Alzheimer's disease and more rapid cognitive decline once diagnosed. Moreover, although Alzheimer's disease is influenced by inflammation, which itself has known sex differences, no study has investigated whether sex differences in memory are moderated by peripheral inflammatory activity. To address this issue, we analyzed data from 109 individuals (50 women, M

Indexed as

Alzheimer DiseaseAgedCytokinesFemaleHumansLongitudinal StudiesMaleMemoryNeuropsychological TestsCytokinesAlzheimer’s diseaseCognitionInflammationMechanismsMemoryPathophysiologyRiskSex differencesSymptomsVulnerability

Identifiers

PMID33301871
PMCPMC8793982
OpenAlexW3112212535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.