ArticleNeuron2020
A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 155 citations in OpenAlex.
- Article
- Optotagging in primate cortex uncovers excitatory and inhibitory neuron specializations in form vision.Nature communications · 2026Article
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
- An inhibitory brainstem pathway reduces visual detection during background motion.Nature communications · 2026Article
- A multimodal approach for visualizing and identifying electrophysiological cell types in vivo.Nature communications · 2026Article
- Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.Neuron · 2026Article
- Feature-tuned excitation of somatostatin interneurons drives figure-ground segregation.Neuron · 2026Article
- How the visual brain can learn to parse images using a multiscale, incremental grouping process.PLoS computational biology · 2026Article
- Comparative transcriptomics reveals differences in cortical cell type organization between metatherian and eutherian mammals.PNAS nexus · 2026Article
- Are we ready to tackle perceptual segmentation of natural scenes?Vision research · 2026Review
- Characteristics and dynamical signatures of recurrent cortical circuits during context-dependent processing.bioRxiv : the preprint server for biology · 2026Article
- Synergistic Geniculate and Cortical Dynamics Facilitate a Decorrelated Spatial Frequency Code in the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal heterogeneity of normalization strength in a circuit model.Science advances · 2026Article
- Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine.National science review · 2025Article
- Prediction of neural activity in connectome-constrained recurrent networks.Nature neuroscience · 2025Article
- Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.bioRxiv : the preprint server for biology · 2025Article
- Context-dependent activation of V1 parvalbumin interneurons enhances visual discrimination.PLoS biology · 2025Article
- Delayed integration of somatostatin interneurons into visual circuits.Nature communications · 2025Article
- Article
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but not when they differ. The underlying mechanisms remain unclear. Here, we use optical recordings, manipulations, and computational modeling to show that disinhibitory circuits consisting of vasoactive intestinal peptide (VIP)-expressing and somatostatin (SOM)-expressing inhibitory neurons modulate responses in mouse visual cortex depending on similarity between stimulus and surround, primarily by modulating recurrent excitation. When stimulus and surround are similar, VIP neurons are inactive, and activity of SOM neurons leads to suppression of excitatory neurons. However, when stimulus and surround differ, VIP neurons are active, inhibiting SOM neurons, which leads to relief of excitatory neurons from suppression. We have identified a canonical cortical disinhibitory circuit that contributes to contextual modulation and may regulate perceptual saliency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.