Evidence map›Paper›PMID 33301414›Full record

ArticleJournal of medical Internet research2020

An Artificial Intelligence Model to Predict the Mortality of COVID-19 Patients at Hospital Admission Time Using Routine Blood Samples: Development and Validation of an Ensemble Model.

Hoon Ko, Heewon Chung, Wu Seong Kang, Chul Park, Do Wan Kim, Seong Eun Kim, Chi Ryang Chung, Ryoung Eun Ko, Hooseok Lee, Jae Ho Seo and 4 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Journal of medical Internet research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  13. Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Hoon Ko *Biomedical Engineering, Wonkwang University, Iksan, Republic of Korea.ORCID 0000-0001-7807-215X
Heewon Chung *Biomedical Engineering, Wonkwang University, Iksan, Republic of Korea.ORCID 0000-0002-4039-1419
Wu Seong Kang *Department of Trauma Surgery, Wonkwang University Hospital, Iksan, Republic of Korea.ORCID 0000-0003-0136-4458
Chul Park *Department of Internal Medicine, Wonkwang University Hospital, Iksan, Republic of Korea.ORCID 0000-0002-6031-009X
Do Wan KimDepartment of Thoracic and Cardiovascular Surgery, Chonnam National University Medical School, Gwangju, Republic of Korea.ORCID 0000-0003-2262-2882
Seong Eun KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.ORCID 0000-0003-0162-6155
Chi Ryang ChungDepartment of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-1830-307X
Ryoung Eun KoDepartment of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-4945-5623
Hooseok LeeBiomedical Engineering, Wonkwang University, Iksan, Republic of Korea.ORCID 0000-0003-1410-425X
Jae Ho SeoDepartment of Biochemistry, Wonkwang University School of Medicine, Iksan, Republic of Korea.ORCID 0000-0002-8466-7800
Tae-Young ChoiDepartment of Pathology, Wonkwang University School of Medicine, Iksan, Republic of Korea.ORCID 0000-0002-3285-0005
Rafael JaimesBiotechnology and Human Systems, Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA, United States.ORCID 0000-0002-5493-0399
Kyung Won KimRadiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID 0000-0002-1532-5970
Jinseok LeeBiomedical Engineering, Wonkwang University, Iksan, Republic of Korea.ORCID 0000-0002-8580-490X
Wonkwang University · KRChonnam National University · KRSamsung Medical Center · KRMIT Lincoln Laboratory · USUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19, which is accompanied by acute respiratory distress, multiple organ failure, and death, has spread worldwide much faster than previously thought. However, at present, it has limited treatments.

objectiveTo overcome this issue, we developed an artificial intelligence (AI) model of COVID-19, named EDRnet (ensemble learning model based on deep neural network and random forest models), to predict in-hospital mortality using a routine blood sample at the time of hospital admission.

methodsWe selected 28 blood biomarkers and used the age and gender information of patients as model inputs. To improve the mortality prediction, we adopted an ensemble approach combining deep neural network and random forest models. We trained our model with a database of blood samples from 361 COVID-19 patients in Wuhan, China, and applied it to 106 COVID-19 patients in three Korean medical institutions.

resultsIn the testing data sets, EDRnet provided high sensitivity (100%), specificity (91%), and accuracy (92%). To extend the number of patient data points, we developed a web application (BeatCOVID19) where anyone can access the model to predict mortality and can register his or her own blood laboratory results.

conclusionsOur new AI model, EDRnet, accurately predicts the mortality rate for COVID-19. It is publicly available and aims to help health care providers fight COVID-19 and improve patients' outcomes.

Indexed as

AdultAgedArtificial IntelligenceChinaCOVID-19FemaleHospitalizationHumansMaleMiddle AgedNeural Networks, ComputerRepublic of KoreaSARS-CoV-2artificial intelligenceblood samplesCOVID-19mortality prediction

Identifiers

PMID33301414
PMCPMC7759509
OpenAlexW3110800647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.