Evidence map›Paper›PMID 33301104›Full record

ReviewCurrent diabetes reports2020

Periodic and Intermittent Fasting in Diabetes and Cardiovascular Disease.

Annunziata Nancy Crupi, Jonathan Haase, Sebastian Brandhorst, Valter D Longo

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07065955 (Effects of the Longevity Diet and the Fasting-mimicking Diet on Body Composition, Risk Factors for Age-related Diseases), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07065955 completednot on this map

Effects of the Longevity Diet and the Fasting-mimicking Diet on Body Composition, Risk Factors for Age-related Diseases

TypeobservationalSponsorFondazione Valter LongoRan2019 to 2024Enrolled365ConditionsOverweight, Obesity, Metabolic Syndrome, Autoimmune DiseasesArmsLongevity diet alone or in combination with fasting mimicking diet
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Remodelling of the gut virome after long-term fasting.NPJ biofilms and microbiomes · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Annunziata Nancy CrupiLongevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0002-5582-0749
Jonathan HaaseLongevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0001-8891-6512
Sebastian BrandhorstLongevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0003-4131-0876
Valter D LongoLongevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. vlongo@usc.edu.
University of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewCardiovascular disease (CVD) is one of the leading causes of death globally. Nutrition plays a central role in CVD risk by affecting aging, adiposity, glycemia, blood pressure, cholesterol, inflammation, and other risk factors and can affect CVD risk not only based on calorie intake and dietary composition but also the timing and range of meals. This review evaluates the effects of fasting, fasting-mimicking diets, and time-restricted eating on the reduction of CVD risk factors and provides initial data on their potential to serve as CVD prevention and treatment therapies. RECENT

findingsIntermittent fasting (IF), time-restricted eating (TRE), prolonged fasting (PF), and fasting-mimicking diets (FMD) show promise in the reduction of CVD risk factors. Results on IF, TRE, PF, and FMD on CVD risk factors are significant and often independent of weight loss, yet long-term studies on their effect on CVD are still lacking. Coupling periodic and prolonged, or intermittent and more frequent cycles of fasting or fasting-mimicking diets, designed to maximize compliance and minimize side effects, has the potential to play a central role in the prevention and treatment of CVD and metabolic syndrome.

Indexed as

Cardiovascular DiseasesDiabetes MellitusDietEnergy IntakeFastingHumansCardiometabolic diseaseFasting mimicking dietIntermittent fastingObesityTime restricted eating

Identifiers

PMID33301104
OpenAlexW3112007159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.