ArticleEpigenomics2020
DNA methylation analysis of candidate genes associated with dementia in peripheral blood.
Open access · greenAbstract read
In one paragraph
Article in Epigenomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.Neuroscience and biobehavioral reviews · 2023Pooled it
- Distinct sex-specific DNA methylation differences in Alzheimer's disease.Alzheimer's research & therapy · 2022Pooled it
- Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer's disease.Nature communications · 2022Pooled it
- Trial
- Blood DNA Methylation Predicts Long-Term Risk of Dementia in Prospective Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026Review
- Longitudinal Analysis of Mitochondrial D-Loop Methylation and Copy Number in Peripheral Blood: Epigenetic Signatures of Alzheimer's Disease Progression and Aging.International journal of molecular sciences · 2026Article
- "Assessing relationship between blood MAPT methylation levels and clinical expression in Frontotemporal Dementia".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Observational
- Blood DNA methylation signature for incident dementia: Evidence from longitudinal cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- DNA methylation and the APP gene: dietary influences in the context of Alzheimer's disease-a mini review.Frontiers in nutrition · 2025Review
- MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer's disease.Database : the journal of biological databases and curation · 2024Article
- APOE 5'UTR Methylation Pattern Analysis in Blood and Brain Tissue from Alzheimer's Disease Affected Patients.Aging and disease · 2024Article
- Epigenetics in Alzheimer's Disease: A Critical Overview.International journal of molecular sciences · 2024Review
- Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late-onset dementia due to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- DNA Methylation in Aging and Alzheimer's Disease.Human brain (Hong Kong) · 2024Article
- Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects.Alzheimer's research & therapy · 2023Article
- Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects.Research square · 2023Article
- Utility of DNA Methylation as a Biomarker in Aging and Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Review
- Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.Nature reviews. Neurology · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Peter D FransquetSchool of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia.ORCID 0000-0002-3515-0557
Paul LacazeSchool of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia.ORCID 0000-0002-0902-6798
Richard SafferyMurdoch Children's Research Institute & Department of Paediatrics, The University of Melbourne, Parkville, 3052 Victoria, Australia.ORCID 0000-0002-9510-4181
James PhungSchool of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia.
Emily ParkerSchool of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia.
Raj C ShahDepartment of Family Medicine & Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0001-9706-9730
Anne MurrayBerman Center for Outcomes & Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare; Division of Geriatrics, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Robyn L WoodsSchool of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia.
Joanne RyanSchool of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia.ORCID 0000-0002-7039-6325
Monash University · AUInserm · FRRush University Medical Center · USThe University of Melbourne · AUUniversity of Minnesota · US
Funding
ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6MAustralian Government RTP ScholarshipDementia Research Leader Fellowship APP1135727National Health and Medical Research Council (NHMRC) of Australia 1127060National Health and Medical Research Council (NHMRC) of Australia 334047NIA NIH HHS U01 AG029824
Abstract
PubMed holds no abstract for this paper.
Indexed as
DNA MethylationAgedAged, 80 and overalpha-SynucleinAmyloid beta-Protein PrecursorApolipoproteins EBrain-Derived Neurotrophic FactorDementiaFemaleHumansMaleMembrane Transport ProteinsMental Status and Dementia TestsMitochondrial Precursor Protein Import Complex ProteinsNIMA-Interacting Peptidylprolyl Isomerasealpha-SynucleinAmyloid beta-Protein PrecursorApoE protein, humanApolipoproteins EAPP protein, humanBDNF protein, humanBrain-Derived Neurotrophic FactorMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsNIMA-Interacting Peptidylprolyl IsomerasePIN1 protein, humanSNCA protein, humanTOMM40 protein, humanAPOEAPPBDNFbiomarkerblooddementiaDNA methylationPIN1SNCATOMM40
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.