ReviewHuman brain mapping2022
Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.
Review in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Schizophrenia and bipolar disorder: a comparative analysis of genetic and brain network connectivity.Psychological medicine · 2026Article
- Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults.Human brain mapping · 2025Article
- NeuroDISK: An AI Approach to Automate Continuous Inquiry-Driven Discoveries in Neuroimaging Genetics.bioRxiv : the preprint server for biology · 2025Article
- Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol.Developmental cognitive neuroscience · 2024Article
- Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture.Stem cell reports · 2024Article
- Growing Up Together in Society (GUTS): A team science effort to predict societal trajectories in adolescence and young adulthood.Developmental cognitive neuroscience · 2024Article
- Investigating the genetic relationship of intracranial and subcortical brain volumes with depression and other psychiatric disorders.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Population Neuroscience: Principles and Advances.Current topics in behavioral neurosciences · 2024Review
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- Shared molecular genetic factors influence subcortical brain morphometry and Parkinson's disease risk.NPJ Parkinson's disease · 2023Article
- Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample.Molecular psychiatry · 2022Article
- Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives.Translational psychiatry · 2022Review
- Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A longitudinal multi-scanner multimodal human neuroimaging dataset.Scientific data · 2022Article
- Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease.Acta neuropathologica · 2022Article
- Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs.Human brain mapping · 2022Review
- Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.Human brain mapping · 2022Review
- The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping.Human brain mapping · 2022Article
- Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Here we review the motivation for creating the enhancing neuroimaging genetics through meta-analysis (ENIGMA) Consortium and the genetic analyses undertaken by the consortium so far. We discuss the methodological challenges, findings, and future directions of the genetics working group. A major goal of the working group is tackling the reproducibility crisis affecting "candidate gene" and genome-wide association analyses in neuroimaging. To address this, we developed harmonized analytic methods, and support their use in coordinated analyses across sites worldwide, which also makes it possible to understand heterogeneity in results across sites. These efforts have resulted in the identification of hundreds of common genomic loci robustly associated with brain structure. We have found both pleiotropic and specific genetic effects associated with brain structures, as well as genetic correlations with psychiatric and neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.