Evidence map›Paper›PMID 33300564›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Optimizing Screening for Anorectal, Pharyngeal, and Urogenital Chlamydia trachomatis and Neisseria gonorrhoeae Infections in At-Risk Adolescents and Young Adults in New Orleans, Louisiana and Los Angeles, California, United States.

Olivia M Man, Wilson E Ramos, Gabriella Vavala, Cameron Goldbeck, Manuel A Ocasio, Jasmine Fournier, Adriana Romero-Espinoza, M Isabel Fernandez, Dallas Swendeman, Sung-Jae Lee and 3 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03134833 (Engaging Seronegative Youth to Optimize HIV Prevention Continuum), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03134833 nacompletednot on this map

Engaging Seronegative Youth to Optimize HIV Prevention Continuum

TypeinterventionalSponsorUniversity of California, Los AngelesRan2017 to 2022Enrolled1,478ConditionsHIV, Mental Health, Substance Use, STIArmsAutomated Messaging & Monitoring, Peer Support, Coaching
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Unveiling the immune dynamics ofInfection and immunity · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Alternative strategies forFrontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Olivia M ManDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Wilson E RamosDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Gabriella VavalaDivision of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Cameron GoldbeckDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Manuel A OcasioSection of Adolescent Medicine, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Jasmine FournierSection of Adolescent Medicine, Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Adriana Romero-EspinozaDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
M Isabel FernandezNova Southeastern University, Fort Lauderdale, Florida, USA.
Dallas SwendemanDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Sung-Jae LeeDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Scott ComuladaDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Mary Jane Rotheram-BorusDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Jeffrey D KlausnerDivision of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USTulane University · USNova Southeastern University · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Nina Thawata Harawa · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
Optimizing the HIV Treatment Continuum with a Stepped Care Model for Youth Living with HIVU19HD089886 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FERNANDEZ, MARIA ISABEL, ROTHERAM-BORUS, MARY JANE · 2016 to 2022
$23.4M
NIAID NIH HHS P30 AI028697NICHD NIH HHS U19 HD089886NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

backgroundPublic health organizations have inconsistent recommendations for screening adolescents and young adults for Chlamydia trachomatis and Neisseria gonorrhoeae infections. Guidelines suggest different combinations of anorectal, pharyngeal, and urogenital testing based on age, sex, and sexual activity. Further evaluation of how identity and behaviors impact the anatomic distribution of C. trachomatis and N. gonorrhoeae infection is needed to optimize future screening practices.

methodsWe assessed the positivity of C. trachomatis and N. gonorrhoeae infections at different anatomic sites in a cohort of at-risk sexually active adolescents and young adults aged 12-24 years in New Orleans, Louisiana and Los Angeles, California. Participants were tested for C. trachomatis and N. gonorrhoeae at 3 sites (anorectum, pharynx, and urethral/cervix) every 4 months using self-collected swabs. We stratified anatomic distributions of infection into 4 gender and sexual behavior categories: (1) cisgender men who have sex with men and transgender women (MSMTW); (2) cisgender heterosexual males; (3) cisgender heterosexual females; and (4) gender minorities assigned female at birth.

resultsWhile three-site testing detected all infections, two-site (anorectum and urethra/cervix) testing identified 92%-100% of C. trachomatis or N. gonorrhoeae infections in participants assigned female at birth and cisgender heterosexual males. For MSMTW, two-site anorectal and pharyngeal testing vs single-site anorectal testing increased the proportion of individuals with either infection from 74% to 93%.

conclusionsSexual behavior and gender identity may influence detection of C. trachomatis and N. gonorrhoeae infections at specific anatomic testing sites. Testing guidelines should incorporate sexual behavior and gender identity. CLINICAL TRIALS REGISTRATION: NCT03134833.

Indexed as

Chlamydia InfectionsGonorrheaSexual and Gender MinoritiesAdolescentChildChlamydia trachomatisFemaleGender IdentityHomosexuality, MaleHumansLos AngelesLouisianaMaleNeisseria gonorrhoeaeNew OrleansPharynxadolescentsanatomic distributionChlamydia trachomatisNeisseria gonorrhoeaescreening practices

Identifiers

PMID33300564
PMCPMC8825228
OpenAlexW3112670030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.