ArticleBrain and behavior2021
Neural correlates of reward processing: Functional dissociation of two components within the ventral striatum.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
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- Trait reward sensitivity and behavioral motivation are associated with connectivity between the default mode network and the striatum during reward anticipation.bioRxiv : the preprint server for biology · 2025Article
- Morphometric Evidence of a U-Shaped Relationship Between Loss Aversion and Posterior Insular/Somatosensory Cortical Features.Human brain mapping · 2025Article
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- Modeling and validation in Parkinson's disease patients with frailty.Frontiers in neuroscience · 2025Article
- Diffusion and structural MRI as potential biomarkers in people with Parkinson's disease and cognitive impairment.European radiology · 2024Article
- Age-related differences in ventral striatal and default mode network function during reciprocated trust.NeuroImage · 2022Article
- Cortico-Striatal Activity Characterizes Human Safety Learning via Pavlovian Conditioned Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neural Connectivity Underlying Reward and Emotion-Related Processing: Evidence From a Large-Scale Network Analysis.Frontiers in systems neuroscience · 2022Article
- Neural correlates of reward processing: Functional dissociation of two components within the ventral striatum.Brain and behavior · 2021Article
- Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging.Frontiers in human neuroscience · 2021Article
- From surface to depth: Using deep learning to predict striatal fMRI reward signaling from EEG.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
introductionRewarding and punishing stimuli elicit BOLD responses in the affective division of the striatum. The responses typically traverse from the affective to the associative division of the striatum, suggesting an involvement of associative processes during the modulation of stimuli valance. In this study, we hypothesized that fMRI responses to rewards versus punishments in a guessing card game can be disassociated into two functional component processes that reflect the convergence of limbic and associative functional networks in the ventral striatum.
methodsWe used fMRI data of 175 (92 female) subjects from the human connectome project´s gambling task, working memory task, and resting-state scans. A reward > punish contrast identified a ventral striatum cluster from which voxelwise GLM parameter estimates were entered into a k-means clustering algorithm. The k-means analysis supported separating the cluster into two spatially distinct components. These components were used as seeds to investigate their functional connectivity profile. GLM parameter estimates were extracted and compared from the task contrasts reward > punish and 2-back > 0-back from two ROIs in the ventral striatum and one ROI in hippocampus.
resultsThe analyses converged to show that a superior striatal component, coupled with the ventral attention and frontal control networks, was responsive to both a modulation of cognitive control in working memory and to rewards, whereas the most inferior part of the ventral striatum, coupled with the limbic and default mode networks including the hippocampus, was selectively responsive to rewards.
conclusionWe show that the fMRI response to rewards in the ventral striatum reflects a mixture of component processes of reward. An inferior ventral striatal component and hippocampus are part of an intrinsically coupled network that responds to reward-based processing during gambling. The more superior ventral striatal component is intrinsically coupled to networks involved with executive functioning and responded to both reward and cognitive control demands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.