ArticleClinical and experimental dental research2021
The effects of calcitonin on post-orthodontic relapse in rats.
Article in Clinical and experimental dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of mesenchymal stem cell secretome on osteoclast- and osteogenesis-related markers during orthodontic relapse.Journal of Taibah University Medical Sciences · 2026Article
- Effects ofJournal of Taibah University Medical Sciences · 2025Article
- Pulsed electromagnetic field prevents tooth relapse after orthodontic tooth movement in rat models.Journal of Taibah University Medical Sciences · 2025Article
- Effect of vitamin D deficiency on postorthodontic relapse: An animal study.Clinical and experimental dental research · 2023Article
- Article
- The effects of calcitonin on post-orthodontic relapse in rats.Clinical and experimental dental research · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the effects of systematic calcitonin administration on post-orthodontic relapse in rat model. MATERIAL AND
methodsThis experimental animal model involved 36 male Wister rats. The maxillary right first molars were moved mesially, using a modified orthodontic appliance delivered 50 gm, for 14 days, retained for 4 days and left to relapse for 10 days. The study group was divided into three subgroups in which a single injection of calcitonin (20 IU/Kg), three injections of calcitonin (20 IU/Kg), each every other day, and normal saline were administered subcutaneously after orthodontic tooth movement has finished. The relapse ratio, histomorphometric analysis including osteoblasts, osteoclasts numbers and bone area and immunohistochemical analysis including the expression of receptor activator of nuclear factor kappa Β (RANK), receptor activator of nuclear factor kappa Β ligand (RANKL) and osteoprotegerin (OPG) were measured and assessed.
resultsThe relapse ratio was significantly reduced in the three-dose calcitonin group (28%) compared to the single dose calcitonin group (34%) and the control group (46%). This was accompanied by a nonsignificant increase in osteoblasts number and bone area in three-dose calcitonin group and a nonsignificant reduction in osteoclast number. However, the immune histochemical expression of RANK, RANKL and OPG did not show statistically significant difference at the end of relapse period.
conclusionsSystemic administration of three doses of calcitonin may minimize the relapse ratio in experimentally moved rat molars.
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