ArticleMolecular medicine reports2021
Anti‑inflammatory effect of salusin‑β knockdown on LPS‑activated alveolar macrophages via NF‑κB inhibition and HO‑1 activation.
Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Anti-Inflammatory Activity of BiotransformedJournal of microbiology and biotechnology · 2024Article
- XueFu ZhuYu Decoction Alleviates Cardiopulmonary Bypass-Induced NLRP3 Inflammasome-Dependent Pyroptosis by Inhibiting IkB-Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation of alveolar macrophages is the primary pathological factor leading to acute lung injury (ALI), and NF‑κB activation and HO‑1 inhibition are widely involved in inflammation. Salusin‑β has been reported to contribute to the progression of the inflammatory response, but whether salusin‑β could regulate inflammation in lipopolysaccharide (LPS)‑induced ALI remains unknown. The present study aimed to investigate the role of salusin‑β in LPS‑induced ALI and to uncover the potential underlying mechanisms. Sprague‑Dawley rats were subjected to LPS administration, and then pathological manifestations of lung tissues, inflammatory cytokines levels in bronchoalveolar lavage fluid (BALF) and expression of salusin‑β in macrophages of lung tissues were assessed. NR8383 cells with or without salusin‑β knockdown were treated with LPS, and then the concentration of inflammatory cytokines, and the expression of high mobility group box‑1 (HMGB1), NF‑κB signaling molecules and heme oxygenase‑1 (HO‑1) levels were detected. The results showed that LPS caused injury of lung tissues, increased the levels of proinflammatory cytokines in BALF, and led to higher expression of salusin‑β or macrophages in lung tissues of rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.