Evidence map›Paper›PMID 33300011›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.

Anjali Ramaswamy, Nina N Brodsky, Tomokazu S Sumida, Michela Comi, Hiromitsu Asashima, Kenneth B Hoehn, Ningshan Li, Yunqing Liu, Aagam Shah, Neal G Ravindra and 22 more

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 25 citations in OpenAlex.

  1. Treatment of multisystem inflammatory syndrome in children.World journal of pediatrics : WJP · 2024
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 3 institutions in 1 country.

Nina N Brodsky
Tomokazu S SumidaORCID 0000-0002-9806-2642
Michela Comi
Hiromitsu Asashima
Kenneth B Hoehn
Ningshan Li
Yunqing Liu
Aagam Shah
Neal G Ravindra
Jason Bishai
Alamzeb Khan
William Lau
Brian Sellers
Neha Bansal
Pamela Guerrerio
Victoria Habet
Andrew J Rice
Jason Catanzaro
Harsha Chandnani
Merrick Lopez
Charles S Dela Cruz
John S Tsang
Zuoheng Wang
Steven H Kleinstein
David van Dijk
Richard W Pierce
David A Hafler
Yale University · USLoma Linda University · USENT and Allergy · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
Integrative analysis and modeling of human immune responses and pathologiesZIAAI001152 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2022
$14.1M
Systems Immunology of COVID-19ZIAAI001266 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2020 to 2022
$1.2M
Mechanisms of Endothelial Cell Dysfunction in Critically Ill ChildrenK08HL136898 · NHLBI · YALE UNIVERSITY · PI PIERCE, RICHARD W · 2019 to 2023
$780k
Deep and Integrative Analysis of RNA Sequencing Data to Identify Pathogenesis Heterogeneity of Chronic Lung DiseaseR21LM012884 · NLM · YALE UNIVERSITY · PI YAN, XITING · 2018 to 2019
$415k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL136898NIAID NIH HHS T32 AI007019NLM NIH HHS R21 LM012884
6 · The paper itself

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV2 infection in otherwise healthy children. Here, we define immune abnormalities in MIS-C compared to adult COVID-19 and pediatric/adult healthy controls using single-cell RNA sequencing, antigen receptor repertoire analysis, unbiased serum proteomics, and

Identifiers

PMID33300011
PMCPMC7724682
OpenAlexW3109854052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.