Evidence map›Paper›PMID 33299992›Full record

ArticlebioRxiv : the preprint server for biology2020

Transcriptional response modules characterise IL-1β and IL-6 activity in COVID-19.

Lucy Ck Bell, Cem Meydan, Jacob Kim, Jonathan Foox, Daniel Butler, Christopher E Mason, Sagi D Shapira, Mahdad Noursadeghi, Gabriele Pollara

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lucy Ck BellDivision of Infection & Immunity, University College London, London, UK.
Cem MeydanThe HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Jacob KimHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Jonathan FooxThe HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Daniel ButlerThe HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Christopher E MasonThe HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Sagi D ShapiraHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Mahdad NoursadeghiDivision of Infection & Immunity, University College London, London, UK.
Gabriele PollaraDivision of Infection & Immunity, University College London, London, UK.
Cornell University · USColumbia University Irving Medical Center · USRoyal London Hospital · GBRoyal Free London NHS Foundation Trust · GB

Funding

Systematic pharmacological targeting of the core mechanisms responsible for maintaining cancer cell stateU54CA209997 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA, HONIG, BARRY H · 2016 to 2021
$10.9M
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4M
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
Quantitative Studies of influenza EvolutionR01GM109018 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAPIRA, SAGI · 2014 to 2019
$2.6M
Mapping the RNA modification N6-methyladenosine during Zika virus infectionR21AI129851 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI HORNER, STACY MICHELLE, MASON, CHRISTOPHER EDWARD · 2017 to 2018
$469k
NCI NIH HHS U54 CA209997NIAID NIH HHS R01 AI151059NIAID NIH HHS R21 AI129851NIGMS NIH HHS R01 GM109018NIMH NIH HHS R01 MH117406Wellcome Trust
6 · The paper itself

Abstract

Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines

Indexed as

COVID-19IL-1βIL-6modulestranscriptomics

Identifiers

PMID33299992
PMCPMC7724660
OpenAlexW3044259643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.