Evidence map›Paper›PMID 33299987›Full record

ArticlebioRxiv : the preprint server for biology2020

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

Benjamin J Schmiedel, Vivek Chandra, Job Rocha, Cristian Gonzalez-Colin, Sourya Bhattacharyya, Ariel Madrigal, Christian H Ottensmeier, Ferhat Ay, Pandurangan Vijayanand

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 15 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Benjamin J SchmiedelLa Jolla Institute for Immunology, La Jolla, CA, USA.
Vivek ChandraLa Jolla Institute for Immunology, La Jolla, CA, USA.
Job RochaLa Jolla Institute for Immunology, La Jolla, CA, USA.
Cristian Gonzalez-ColinLa Jolla Institute for Immunology, La Jolla, CA, USA.
Sourya BhattacharyyaLa Jolla Institute for Immunology, La Jolla, CA, USA.
Ariel MadrigalLa Jolla Institute for Immunology, La Jolla, CA, USA.
Christian H OttensmeierLa Jolla Institute for Immunology, La Jolla, CA, USA.
Ferhat AyLa Jolla Institute for Immunology, La Jolla, CA, USA.
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, CA, USA.
La Jolla Institute for Immunology · US

Funding

Research Resources: Epigenomic and Transcriptomic Profiles of Human Immune CellsR24AI108564 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI MITCHELL KRONENBERG, Bjoern Peters · 2014 to 2026
$12.1M
Studying the function of human genetic variation in the light of 3D genome organizationR35GM128938 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Ferhat Ay · 2018 to 2026
$4.6M
NIAID NIH HHS R24 AI108564NIGMS NIH HHS R35 GM128938
6 · The paper itself

Abstract

Common genetic polymorphisms associated with severity of COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Here, we assessed the effects of 679 COVID-19-risk variants on gene expression in a wide-range of immune cell types. Severe COVID-19-risk variants were significantly associated with the expression of 11 protein-coding genes, and overlapped with either target gene promoter or

Identifiers

PMID33299987
PMCPMC7724655
OpenAlexW3109891072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.