ArticleiScience2020
A Functionally and Anatomically Bipartite Vocal Pattern Generator in the Rat Brain Stem.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
- Auditory cortex modulates call duration in rats.Communications biology · 2026Article
- Integration of laryngeal and cardiorespiratory control by the dorsomedial and perifornical hypothalamus in anaesthetised rats.Frontiers in neuroscience · 2026Article
- Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node.Current biology : CB · 2025Article
- A humanized NOVA1 splicing factor alters mouse vocal communications.Nature communications · 2025Article
- Hypothalamic Regulation of Cardiorespiratory Functions: Insights into the Dorsomedial and Perifornical Pathways.Biology · 2024Review
- Uncovering the neural control of laryngeal activity and subglottic pressure in anaesthetized rats: insights from mesencephalic regions.Pflugers Archiv : European journal of physiology · 2024Article
- Article
- Brainstem control of vocalization and its coordination with respiration.Science (New York, N.Y.) · 2024Article
- Central Autonomic Mechanisms Involved in the Control of Laryngeal Activity and Vocalization.Biology · 2024Review
- Midbrain node for context-specific vocalisation in fish.Nature communications · 2024Article
- Article
- Deglutition and the Regulation of the Swallow Motor Pattern.Physiology (Bethesda, Md.) · 2023 · on this mapReview
- Large-Scale Mapping of Vocalization-Related Activity in the Functionally Diverse Nuclei in Rat Posterior Brainstem.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents.Molecular autism · 2022Review
- Optogenetic stimulation of pre-Bötzinger complex reveals novel circuit interactions in swallowing-breathing coordination.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hearing, touching, and multisensory integration during mate choice.Frontiers in neural circuits · 2022Review
- Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian vocal pattern generator is situated in the brainstem but its exact structure is debated. We mapped these circuits in rats by cooling and microstimulation. Local cooling disrupted call production above an anterior and a posterior brainstem position. Anterior cooling affected predominantly high-frequency calls, whereas posterior cooling affected low-frequency calls. Electrical microstimulation of the anterior part led to modulated high-frequency calls, whereas microstimulation of the posterior part led to flat, low-frequency calls. At intermediate positions cooling did not affect calls and stimulation did not elicit calls. The anterior region corresponds to a subsection of the parvicellular reticular formation that we term the vocalization parvicellular reticular formation (VoPaRt). The posterior vocalization sites coincide with the nucleus retroambiguus (NRA). VoPaRt and NRA neurons were very small and the VoPaRt was highly myelinated, suggestive of high-speed processing. Our data suggest an anatomically and functionally bipartite vocal pattern generator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.