Evidence map›Paper›PMID 33299856›Full record

ArticleBioMed research international2020

GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis.

Xueting Luo, Xiaowei Shi, Zhongguang Sun, Jing Xiao, Hui Song, Guo Lu, Xin Xu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xueting LuoSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0002-5628-0772
Xiaowei ShiSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0001-6153-5250
Zhongguang SunSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0002-8046-9153
Jing XiaoSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0001-7364-3718
Hui SongSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0002-8796-9660
Guo LuSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0003-0037-8903
Xin XuSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.ORCID https://orcid.org/0000-0003-1919-7563
Shanghai University of Sport · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCombined aerobic and resistance training has been demonstrated to benefit glycemic control and reverse nonalcoholic fatty liver disease in childhood obesity. General control nonderepressible 2 (GCN2) deficiency has been reported to attenuate hepatic steatosis and insulin resistance. However, whether GCN2 impacts the positive effects of combined aerobic and resistance exercise remains unknown.

objectivesTo investigate whether combined aerobic and resistance exercise improves hepatic steatosis and glucose intolerance and the role GCN2 plays in mediating the metabolic regulation of exercise.

methodsWild-type (WT) and

resultsThe body weight of WT and GCN2KO mice continued to increase until the end of the experiment. The liver weights, hepatic triglyceride content, and AST and ALT levels of the exercised mice were significantly reduced compared to those of the sedentary mice. Exercise improved blood glucose levels and glucose clearance ability in the WT mice, but the glucose intolerance of GCN2KO mice was not improved. Exercise increased PGC-1

conclusionCombined aerobic and resistance exercise had positive effects on hepatic steatosis and the control of glucose intolerance. GCN2 was found to be necessary for exercise-induced improved glucose intolerance. However, the better efficacy in improving hepatic steatosis by exercise in the

Indexed as

Physical Conditioning, AnimalActivating Transcription Factor 4Adenylate KinaseAnimalsDiet, High-FatEukaryotic Initiation Factor-2GlycolipidsLipid MetabolismLiverMaleMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseaseOrgan SizePPAR alphaProtein Serine-Threonine KinasesActivating Transcription Factor 4Adenylate KinaseEif2ak4 protein, mouseEukaryotic Initiation Factor-2GlycolipidsPPAR alphaProtein Serine-Threonine KinasesSirtuin 1Triglycerides

Identifiers

PMID33299856
PMCPMC7707946
OpenAlexW3107344574

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.